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Title:
ピラゾールカルボン酸アミドの調製方法
Document Type and Number:
Japanese Patent JP5684897
Kind Code:
B2
Abstract:
The invention relates to a process for the preparation of formula (I) which process comprises a) reacting a compound of formula (II), wherein X is chloro or bromo, with an organometallic species to (III), wherein X is chloro or bromo; reacting the halobenzyne with a fulvene (IV), to a compound of formula (V) wherein X is chloro or bromo; b) hydrogenating V in the presence of a suitable metal catalyst to a compound of formula (VI) wherein X is chloro or bromo; and either c1) reacting the compound of formula VI with NH3 in the presence of a catalyst comprising palladium and at least one ligand to the compound of formula (VII); and d) reacting the compound of formula VII in the presence of a base with a compound of formula (VIII), to the compound of formula I; or c2 reacting the compound of formula (VI) in the presence of a copper catalyst and a ligand with the compound of formula (VIIIa), to the compound of formula (I).

Inventors:
デニス グリブコフ
レモ ストーラー
トマス フェティガー
ミヒャエル ロメル
Application Number:
JP2013505410A
Publication Date:
March 18, 2015
Filing Date:
April 14, 2011
Export Citation:
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Assignee:
シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト
International Classes:
C07D231/14; C07C25/24
Attorney, Agent or Firm:
Aoki 篤
Ishida 敬
Tsumoru Fukumoto
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Takahide Sasaki