Title:
コピー数変動の決定、方法およびシステム
Document Type and Number:
Japanese Patent JP5707132
Kind Code:
B2
Abstract:
The present invention methods and systems for determining copy number variation of a target polynucleotide in a genome of a subject including amplification based techniques. Methods can include pre-amplification of the sample followed by distribution of sample and a plurality of reaction volumes, quantitative detection of a target polynucleotide and a reference polynucleotide, and analysis so as to determine the relative copy number of the target polynucleotide sequence in the genome of the subject.
Inventors:
Ramakrishnan, Ramesh
Application Number:
JP2010524228A
Publication Date:
April 22, 2015
Filing Date:
September 08, 2008
Export Citation:
Assignee:
Fluidim Corporation
International Classes:
C12Q1/68; C12N15/09
Foreign References:
| US20070202525 |
Other References:
Anal. Chem. (Aug-2007) vol.79, no.19, p.7576-7579
Proc. Natl. Acad. Sci. U.S.A. (1999) vol.96, no.16, p.9236-9241
Proc. Natl. Acad. Sci. U.S.A. (Aug-2007) vol.104, no.32, p.13116-13121
Expert Rev. Mol. Diagn. (2004) vol.4, no.1, p.41-47
Proc. Natl. Acad. Sci. U.S.A. (1999) vol.96, no.16, p.9236-9241
Proc. Natl. Acad. Sci. U.S.A. (Aug-2007) vol.104, no.32, p.13116-13121
Expert Rev. Mol. Diagn. (2004) vol.4, no.1, p.41-47
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita