Title:
高濃度の低粘度懸濁液
Document Type and Number:
Japanese Patent JP5711138
Kind Code:
B2
Abstract:
The present invent ion also provides a high concentration low viscosity suspension of an pharmaceutically acceptable solvent with one or more sub-micron or micron-sized non-crystalline particles comprising one or more proteins or peptides. Optionally one or more additives in the pharmaceutically acceptable solvent to form a high concentration low viscosity suspension with a concentration of at least 20 mg/ml and a solution viscosity of between 2 and 100 centipoise that is suspendable upon shaking or agitation, wherein upon delivery the one or more sub-micron or micron-sized peptides dissolves and do not form peptide aggregates syringeable through a 21 to 27-gauge needle.
Inventors:
Johnston Keipee.
Mazusky Maria Andrea
Instrom Joshua
Rodriguez Miguel Angelo
Mazusky Maria Andrea
Instrom Joshua
Rodriguez Miguel Angelo
Application Number:
JP2011536414A
Publication Date:
April 30, 2015
Filing Date:
November 10, 2009
Export Citation:
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
International Classes:
A61K9/10; A61K38/00; A61K38/27; A61K39/00; A61K39/395; A61K39/44; A61K47/04; A61K47/10; A61K47/22; A61K47/26; A61K47/34
Domestic Patent References:
| JP2008525470A | ||||
| JP2003534267A | ||||
| JP2004536036A | ||||
| JP2005500304A |
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shohei Fujimoto
Shuichi Sonomoto
Akihiro Yamamura
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shohei Fujimoto
Shuichi Sonomoto
Akihiro Yamamura