Title:
ポリマー−フォンビルブラント因子結合体
Document Type and Number:
Japanese Patent JP5715983
Kind Code:
B2
Abstract:
The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex between said proteinaceous construct and at least one factor VIII (FVIII) protein. The physiologically acceptable polymer molecule can be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Further the present invention relates to methods for prolonging the in vivo-half-life of VWF or FVIII in the blood of a mammal having a bleeding disorder associated with functional defects of or deficiencies of at least one of FVIII or VWF.
Inventors:
Friedrich shy flinger
Peter Tresek
Yogan seekman
Peter Tresek
Yogan seekman
Application Number:
JP2012081700A
Publication Date:
May 13, 2015
Filing Date:
March 30, 2012
Export Citation:
Assignee:
BAXTER INTERNATIONAL INCORP0RATED
Baxter Healthcare SA
Baxter Healthcare SA
International Classes:
C07K14/755; A61K38/00; A61P7/04; C07K14/745
Domestic Patent References:
| JP11513378A |
Foreign References:
| WO1994015625A1 | ||||
| WO2004075923A2 | ||||
| US6037452 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita