Title:
抗カドヘリン抗体
Document Type and Number:
Japanese Patent JP5723270
Kind Code:
B2
Abstract:
It is an object of the present invention to provide an anti-cadherin antibody having high antibody-dependent cellular cytotoxicity. The present invention provides an anti-cadherin antibody, which recognizes any one of an upstream region of EC1, a cadherin domain 4 (EC4) and a cadherin domain 5 (EC5), wherein an antibody-dependent cellular cytotoxicity at an antibody concentration of 1 µg/mL is 30% or more.
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Inventors:
Hiroyuki Yutani
Zhang Rein
Keisuke Ishii
Katsushi Koda
Aya Sakamoto
Keiko Katsumi
Hiroshi Onishi
Yoko Ayukawa
Zhang Rein
Keisuke Ishii
Katsushi Koda
Aya Sakamoto
Keiko Katsumi
Hiroshi Onishi
Yoko Ayukawa
Application Number:
JP2011511471A
Publication Date:
May 27, 2015
Filing Date:
April 30, 2010
Export Citation:
Assignee:
National University Corporation Tokyo University
Perseus Proteomics Inc.
Perseus Proteomics Inc.
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N5/10
Domestic Patent References:
| JP2008537941A | 2008-10-02 |
Foreign References:
| WO2007102525A1 | 2007-09-13 | |||
| WO2000061739A1 | 2000-10-19 |
Other References:
JPN6014036055; Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｃｅｌｌ Ｂｉｏｌｏｇｙ Ｖｏｌ．１０９, 1989, ｐ．１７８７-１７９４
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes