Title:
過剰増殖細胞の腫瘍抑制因子に基づいた腫瘍崩壊ウイルスに対する感受性を判定する方法
Document Type and Number:
Japanese Patent JP5748656
Kind Code:
B2
Abstract:
The present invention relates to methods for the treatment of cancer using oncolytic viruses such as reoviruses and myxoma virus. In particular, the invention relies on the observation that cancer cells with aberrations in a tumor suppressor are more susceptible to infection with oncolytic viruses than those that contain normal or "wild-type" tumor suppressors. In particular, defects associated with p53, Rb and ATM each render cancer cells susceptible to oncolytic viral therapy.
Inventors:
Kim, mambak
Johnston, Randall N.
Johnston, Randall N.
Application Number:
JP2011510734A
Publication Date:
July 15, 2015
Filing Date:
May 22, 2009
Export Citation:
Assignee:
Jail Pharmaceutical Company Limited
International Classes:
C12Q1/02; C12N15/09; C12Q1/68; G01N33/53
Domestic Patent References:
| JP2006519784A | ||||
| JP2009501230A | ||||
| JP2003530301A | ||||
| JP2004517966A |
Foreign References:
| WO2008031230A1 | ||||
| WO2008112911A1 | ||||
| WO2008011726A1 | ||||
| WO2006094385A1 |
Other References:
KIM MANBOK et al,REOVIRUS AND TUMOR ONCOLYSIS,JOURNAL OF MICROBIOLOGY,KR,2007年 6月 1日,Vol. 45, No. 3,p. 187-192
Guo et al,Biochimica et Biophysica Acta,2008年 2月15日,Vol. 1785,p. 217-231
Guo et al,Biochimica et Biophysica Acta,2008年 2月15日,Vol. 1785,p. 217-231
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Atsushi Honda
Makoto Onda
Atsushi Honda