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Title:
筋原性疾患検出用マーカー及びそれを用いた検出方法
Document Type and Number:
Japanese Patent JP5748736
Kind Code:
B2
Abstract:
It is intended to provide a low invasive and highly sensitive method for detecting myogenic disease without being influenced by exercise stress. The amount of any one or more of miR-1, miR-133a, miR-133b, and miR-206 in the blood of a test subject is measured. When the amount of the miRNA in the blood is statistically significantly higher than that of corresponding miRNA in the blood of a normal individual, it indicates that the test subject is suffering from myogenic disease.

Inventors:
Kazuo Hashido
Hideya Mizuno
Application Number:
JP2012501884A
Publication Date:
July 15, 2015
Filing Date:
February 25, 2011
Export Citation:
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Assignee:
lsip fund management limited liability company
International Classes:
C12Q1/68; C12N15/09; C12N15/113
Domestic Patent References:
JP2012527873A2012-11-12
JPH11313682A1999-11-16
JP2005304481A2005-11-04
JP2012527873A2012-11-12
Foreign References:
WO2009134710A22009-11-05
CN101386848A2009-03-18
Other References:
JPN6011016336; Am J Physiol Cell Physiol vol.293, 2007, pp.c451-c457
JPN6011016337; Experimental Biology and Medicine vol.233 no.2, 2008, pp.131-138
JPN6011016338; J. Cell. Mol. Med. vol.13 no.1, 2009, pp.2-11
JPN6011016339; The FASEB Journal vol.23, 2009, pp.3335-3346
JPN6014039216; CELL Research Vol.18, No.10, 2008, pp.997-1006
JPN6014039219; Proceedings of the National Academy of Sciences of the United States of America Vol.105, No.30, 2008, pp.10513-10518
JPN6015015700; Clinical Chemistry vol.55 no.11, 2009, pp.1977-1983
JPN6015015702; PLoS ONE vol.6 no.3 e18388, 2011, pp.1-6
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma



 
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