Title:
経口用徐放性固形製剤
Document Type and Number:
Japanese Patent JP5749247
Kind Code:
B2
Abstract:
It is intended to avoid dose dumping of a drug and improve the dissolution properties of the drug in the lower gastrointestinal tract, and thereby provide a sustained-release matrix preparation for oral administration that reliably exhibits its main pharmacological effect when orally administered once or twice a day. The present invention provides a sustained-release preparation obtained by mixing of (A) a pharmacologically active drug, (B) hydroxypropyl methylcellulose acetate succinate having a median size (D 50 ) of 40 µm or smaller, (C) a cellulose derivative, and (D) a saccharide or a nonionic water-soluble polymer followed by molding.
Inventors:
Taro Kanamaru
Shinichiro Tajiri
Fukui Sachiko
Kazuhiro Yoshida
Shinichiro Tajiri
Fukui Sachiko
Kazuhiro Yoshida
Application Number:
JP2012500675A
Publication Date:
July 15, 2015
Filing Date:
February 21, 2011
Export Citation:
Assignee:
Daiichi Sankyo Co., Ltd.
International Classes:
A61K47/38; A61K9/20; A61K31/403; A61K31/444; A61K47/10; A61K47/12; A61K47/26; A61K47/32
Domestic Patent References:
| JP2008525313A | 2008-07-17 | |||
| JP2001513752A | 2001-09-04 | |||
| JP2001522794A | 2001-11-20 |
Foreign References:
| WO2006070781A1 | 2006-07-06 | |||
| WO2003000657A1 | 2003-01-03 | |||
| WO2004058715A1 | 2004-07-15 |
Attorney, Agent or Firm:
Kimiki Ishibashi
Noriko Kitano
Imamura Mayu
Yukiko Nakamura
Toshiyasu Takemoto
Hironobu Kodama
Reiko Kanehara
Noriko Kitano
Imamura Mayu
Yukiko Nakamura
Toshiyasu Takemoto
Hironobu Kodama
Reiko Kanehara