Title:
４−ジメチルアミノ−フェニルで置換されているナフチリジン、及び医薬としてのその使用
Document Type and Number:
Japanese Patent JP5754568
Kind Code:
B2
Abstract:
The invention relates to novel substituted naphthyridines of formula 1 as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof. In formula 1, R1 can represent a group A selected from among the group comprising -O-R3, -NR3R4, -CR3R4R5, -(ethyne)-R3, -S-R3, -SO-R3, and SO2-R3, or R1 represents a group B selected from among the group comprising: -C6-10-aryl; -a five-membered to ten-membered, monocyclic or bicyclic heteroaryl containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heteroaryl is linked to the structure according to formula 1 via a C atom or an N atom; -a three-membered to ten-membered, monocyclic or bicyclic, saturated or partially saturated heterocycle containing 1 to 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said heterocycle is linked to the structure according to formula 1 via a C atom or an N atom; and -a 5-membered to 11-membered spiro group which can optionally contain 1, 2, or 3 heteroatoms independently selected from among the group comprising N, O, and S, wherein said spiro group is linked to the structure according to formula 1 via a C atom or an N atom, wherein said group B can be optionally substituted as described in claims 1, and R3, R4, R5, R6, and m can have the meanings indicated in claim 1. The invention also relates to pharmaceutical compositions containing said compounds.
Inventors:
Figen, Dennis
Huntshoe, sandra
Hobby, Zirke
Hoffman, Matthias
Takeshi Kono
Yayoi Sato
Schnapp, Andreas
Schuler-Mets, Anette
Huntshoe, sandra
Hobby, Zirke
Hoffman, Matthias
Takeshi Kono
Yayoi Sato
Schnapp, Andreas
Schuler-Mets, Anette
Application Number:
JP2011521515A
Publication Date:
July 29, 2015
Filing Date:
July 23, 2009
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
International Classes:
C07D471/04; A61K31/4375; A61P1/04; A61P1/16; A61P7/00; A61P7/06; A61P9/00; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/00; A61P19/10; A61P21/04; A61P25/00; A61P27/02; A61P29/00; A61P35/02; A61P37/08; C07D519/00
Domestic Patent References:
| JP2011529932A | ||||
| JP56020588A |
Foreign References:
| WO2003057695A1 |
Other References:
Charles L. Cywin et al.,Bioorganic & Medicinal Chemistry Letters,2003年,Vol.13,p.1415-1418
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Fusayuki Saito