Title:
ヌクレオリンを介したがん診断および治療のための検査方法
Document Type and Number:
Japanese Patent JP5758962
Kind Code:
B2
Abstract:
Based on the discovery that nucleolin is a specific receptor to endostatin, in the invention a kit is provided. The kit is used for detecting and screening the cancerous types and individuals that are adapted to be treated by using endostatin and other angiogenesis inhibitors. Specially, the detection kit can include the antibody to nucleolin and DNA or RNA combined with coding nucleic acids of nucleolin. In the invention, a screening method for angiogenesis inhibitors is provided, especially those similar inhibitors to endostatin. Furthermore, methods for specifically inhibiting growth of endothelial cells and generation of tumor blood vessels are provided by coupling cytotoxin such as tumor necrosis factor ± with the antibody to nuleolin..
Inventors:
Eisho
Tiger soldiers and stones
Table soldier . Zhang
Tiger soldiers and stones
Table soldier . Zhang
Application Number:
JP2013194024A
Publication Date:
August 05, 2015
Filing Date:
September 19, 2013
Export Citation:
Assignee:
TSINGHUA UNIVERSITY
International Classes:
G01N33/68; A61K38/00; A61P35/00; A61P43/00; G01N33/15; G01N33/50; G01N33/566
Domestic Patent References:
| JP2005526968A | ||||
| JP2003180368A |
Foreign References:
| WO2003086174A1 | ||||
| WO2004091383A1 | ||||
| WO2005035579A1 |
Other References:
Joo EJ et al.,Nucleolin: acharan sulfate-binding protein on the surface of cancer cells,Glycobiology,2005年 1月,15(1),1-9
Attorney, Agent or Firm:
Kiyoji Kuzuwa