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Title:
乱用防止制御放出オピオイド投薬形態
Document Type and Number:
Japanese Patent JP5765820
Kind Code:
B2
Abstract:
Abuse-resistant, controlled release opioid tablets are a combination containing an opioid antagonist such as naloxone at a level above that needed to suppress the euphoric effect of the opioid, if the combination were crushed to break the controlled release properties causing the opioid and opioid antagonist to be released as a immediate release product as a single dose. The controlled release nature of the table prevents the accumulation of orally effective amounts of opioid antagonist when taken normally. The opioid antagonist is contained in a controlled-release matrix and released, over time, with the opioid.

Inventors:
Frank S. Carso
Huay-Hung Khao
Application Number:
JP2012204455A
Publication Date:
August 19, 2015
Filing Date:
September 18, 2012
Export Citation:
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Assignee:
Mundi Pharma International Corporation Limited
International Classes:
A61K9/22; A61K9/20; A61K9/52; A61K31/135; A61K31/473; A61K31/485; A61K45/00; A61K47/04; A61K47/12; A61K47/20; A61K47/32; A61K47/38; A61P25/04
Domestic Patent References:
JP9505602A
Foreign References:
WO2000038656A1
WO1999032119A1
US4457933
WO1999032120A1
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto