Title:
ＤＮＡコード化ライブラリを作製およびスクリーニングする方法
Document Type and Number:
Japanese Patent JP5770641
Kind Code:
B2
Abstract:
The present invention features a number of methods for identifying one or more compounds that bind to a biological target. The methods include synthesizing a library of compounds, wherein the compounds contain a functional moiety having one or more diversity positions. The functional moiety of the compounds is operatively linked to an initiator oligonucleotide that identifies the structure of the functional moiety.
Inventors:
Wagner Richard W.
Application Number:
JP2011550313A
Publication Date:
August 26, 2015
Filing Date:
February 16, 2010
Export Citation:
Assignee:
X-Chem Incorporated
International Classes:
C12N15/09; C40B40/06
Domestic Patent References:
| JP2008543289A | ||||
| JP2004536162A |
Other References:
Clark et al.,Nature chemical biology,Vol.5, No.9,p.647-654(2009.9)
"Supplementary Methods for ClarK et.al."Desigen,Synthesis and Selection of DNA-Encoded Small Molecule Libraries"",Retrieved from internet,URL:http//www.nature.com/nchembio/journal/v5/n9/suppinfo/nchembio.211_S1.html
Ito et al.,Biotechnology Progress,Vol.10, No.4,p.398-402(1994)
"Supplementary Methods for ClarK et.al."Desigen,Synthesis and Selection of DNA-Encoded Small Molecule Libraries"",Retrieved from internet,URL:http//www.nature.com/nchembio/journal/v5/n9/suppinfo/nchembio.211_S1.html
Ito et al.,Biotechnology Progress,Vol.10, No.4,p.398-402(1994)
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
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