Title:
第ＶＩＩＩ因子を含有する安定な医薬組成物
Document Type and Number:
Japanese Patent JP5770775
Kind Code:
B2
Abstract:
A method for preparing a lyophilisate, comprising: (a) preparing of a solution comprising; factor VIII in a concentration ranging from 50 to 10,000 international units/ml, a surfactant in a concentration ranging from above critical micellar concentration to 1% v/v, calcium chloride in a concentration ranging from 0.5 to 10 mM, sucrose in a concentration ranging from 5 to 50 mM, sodium chloride in a concentration ranging from 0.15 to 0.5 M, trisodium citrate in a concentration ranging from 1 to 50 mM, and a buffer in a concentration ranging from 1 to 50 mM, and (b) lyophilising the solution. The invention also relates to the lyophilisate obtainable by said method and a liquid pharmaceutical composition prepared therefrom.
Inventors:
White, marie
Web, paul
Web, paul
Application Number:
JP2013085801A
Publication Date:
August 26, 2015
Filing Date:
April 16, 2013
Export Citation:
Assignee:
IPSEN PHARMA S.A.S.
International Classes:
A61K31/495; A61K38/43; A61K9/08; A61K9/19; A61K38/37; A61K47/02; A61K47/04; A61K47/12; A61K47/18; A61K47/26; A61K47/34; A61K47/36; A61P7/04
Domestic Patent References:
| JP8099999A | ||||
| JP64085927A | ||||
| JP4217630A | ||||
| JP62081327A |
Foreign References:
| WO2000048635A1 | ||||
| WO2001068109A1 |
Attorney, Agent or Firm:
Axis International Patent Business Corporation