Title:
筋萎縮性側索硬化症マーカー及びその利用
Document Type and Number:
Japanese Patent JP5787895
Kind Code:
B2
Abstract:
An object is to provide a biomarker specific to amyotrophic lateral sclerosis and a use thereof. Provided are a marker for amyotrophic lateral sclerosis containing a transmembrane glycoprotein nmb, and a method for detecting amyotrophic lateral sclerosis, which utilizes the marker, and the like.
Inventors:
Hideaki Hara
Masamitsu Shimazawa
Hikotaka Tanaka
Masamitsu Shimazawa
Hikotaka Tanaka
Application Number:
JP2012539646A
Publication Date:
September 30, 2015
Filing Date:
September 20, 2011
Export Citation:
Assignee:
Hideaki Hara
International Classes:
G01N33/68; G01N33/53
Domestic Patent References:
| JP2009528059A | 2009-08-06 | |||
| JP2007528487A | 2007-10-11 |
Other References:
JPN6011067683; Ｊｏｈａｎｎｅｓ ＢＲＥＴＴＳＣＨＮＥＩＤＥＲ ｅｔ ａｌ．: 'Ｐｒｏｔｅｏｍｅ Ａｎａｌｙｓｉｓ ｏｆ Ｃｅｒｅｂｒｏｓｐｉｎａｌ Ｆｌｕｉｄ ｉｎ Ａｍｙｏｔｒｏｐｈｉｃ Ｌａｔｅｒａｌ Ｓｃｌｅｒｏｓｉｓ（ＡＬＳ）' Ｎｅｕｒｏｃｈｅｍ． Ｒｅｓ． Ｖｏｌ．３３，Ｎｏ．１１, 200805, Ｐ．２３５８-２３６３
JPN6011067682; 祖父江元: '筋萎縮性側索硬化症の画期的診断・治療法に関する研究' 筋萎縮性側索硬化症の画期的診断・治療法に関する研究 平成１７-１９年度 総合研究報告書 , 200803, Ｐ．１-７
JPN6015024767; Ｊａｎ Ｊ．Ｍ． ｖａｎ Ｇｒｏｎｉｎｇｅｎ ｅｔ ａｌ．: 'ｎｍｄ， ａ ｎｏｖｅｌ ｇｅｎｅ ｄｉｆｆｅｒｅｎｔｉａｌｌｙ ｅｘｐｒｅｓｓｅｄ ｉｎ ｈｕｍａｎ ｍｅｌａｎｏｍａ ｃｅｌｌ ｌｉｎｅｓ， ｅｎｃｏｄｅｓ ａ ｎｅｗ ａｔｙｐｉｃａｌ ｍｅｍｂ' ＦＥＢＳ Ｌｅｔｔｅｒｓ Ｖｏｌ．４０４，Ｎｏ．１, 19970301, Ｐ．８２-８６
JPN6015024768; Ｘｉａｏｚｈｏｎｇ Ｑｉａｎ ｅｔ ａｌ．: 'Ｐｈａｒｍａｃｏｌｏｇｉｃａｌｌｙ ｅｎｈａｎｃｅｄ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ＧＰＮＭＢ ｉｎｃｒｅａｓｅｓ ｔｈｅ ｓｅｎｓｉｔｉｖｉｔｙ ｏｆ ｍｅｌａｎｏｍａ ｃｅｌｌｓ ｔｏ ｔｈｅ ＣＲ' Ｍｏｌｅｃｕｌａｒ Ｏｎｃｏｌｏｇｙ Ｖｏｌ．２，Ｎｏ．１, 20080601, Ｐ．８１-９３
JPN6011067682; 祖父江元: '筋萎縮性側索硬化症の画期的診断・治療法に関する研究' 筋萎縮性側索硬化症の画期的診断・治療法に関する研究 平成１７-１９年度 総合研究報告書 , 200803, Ｐ．１-７
JPN6015024767; Ｊａｎ Ｊ．Ｍ． ｖａｎ Ｇｒｏｎｉｎｇｅｎ ｅｔ ａｌ．: 'ｎｍｄ， ａ ｎｏｖｅｌ ｇｅｎｅ ｄｉｆｆｅｒｅｎｔｉａｌｌｙ ｅｘｐｒｅｓｓｅｄ ｉｎ ｈｕｍａｎ ｍｅｌａｎｏｍａ ｃｅｌｌ ｌｉｎｅｓ， ｅｎｃｏｄｅｓ ａ ｎｅｗ ａｔｙｐｉｃａｌ ｍｅｍｂ' ＦＥＢＳ Ｌｅｔｔｅｒｓ Ｖｏｌ．４０４，Ｎｏ．１, 19970301, Ｐ．８２-８６
JPN6015024768; Ｘｉａｏｚｈｏｎｇ Ｑｉａｎ ｅｔ ａｌ．: 'Ｐｈａｒｍａｃｏｌｏｇｉｃａｌｌｙ ｅｎｈａｎｃｅｄ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ＧＰＮＭＢ ｉｎｃｒｅａｓｅｓ ｔｈｅ ｓｅｎｓｉｔｉｖｉｔｙ ｏｆ ｍｅｌａｎｏｍａ ｃｅｌｌｓ ｔｏ ｔｈｅ ＣＲ' Ｍｏｌｅｃｕｌａｒ Ｏｎｃｏｌｏｇｙ Ｖｏｌ．２，Ｎｏ．１, 20080601, Ｐ．８１-９３
Attorney, Agent or Firm:
Mikiharu Hagino