Title:
アルドラーゼ、それらをコードする核酸ならびにそれらの作製および使用方法
Document Type and Number:
Japanese Patent JP5793487
Kind Code:
B2
Abstract:
This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.
Inventors:
Burke, Ellen
Hicks, Paula, M.
Peter, Raginbourg
Richardson, Toby
Weiner, David, Pea.
Chao, Leshan
Hicks, Paula, M.
Peter, Raginbourg
Richardson, Toby
Weiner, David, Pea.
Chao, Leshan
Application Number:
JP2012225075A
Publication Date:
October 14, 2015
Filing Date:
October 10, 2012
Export Citation:
Assignee:
BSF Enzymes LLC
International Classes:
C12N15/09; A01H1/00; A01H5/00; A01H5/10; A01K67/027; A21D2/26; A23K1/16; A23K1/165; A23L1/305; A23L2/38; A23L27/30; A23L29/00; A61K9/06; A61K9/08; A61K9/12; A61K9/14; A61K9/20; A61K9/48; A61K38/51; A61K48/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/88; C12P7/04; C12P7/06; C12P7/16; C12P7/50; C12P13/14
Foreign References:
| WO2004027075A2 | ||||
| WO2005042756A2 |
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Nozomi Murabayashi
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Nozomi Murabayashi