Title:
環状ペプチド及びこれを含有する医薬
Document Type and Number:
Japanese Patent JP5804463
Kind Code:
B2
Abstract:
Provided is a novel compound which has excellent inhibitory activity for A² aggregation, and which is useful as a drug. A cyclic peptide or a salt thereof, the cyclic peptide having an amino acid sequence represented by the following formula (1):
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒX-Leu-Val-Y 1 -Y 2 €ƒ€ƒ€ƒ€ƒ€ƒ(1)
(wherein X is Lys, Arg, His, Ala, Gly, Ser, or Thr; and Y 1 and Y 2 , which are identical to or different from each other, each represent a group represented by the following formula (2) :
(wherein Ar 1 represents an aromatic hydrocarbon group or an aromatic heterocyclic group (the aromatic hydrocarbon group or the aromatic heterocyclic group may have 1 to 5 substituents selected from the group consisting of an alkyl group, a cycloalkyl group, a haloalkyl group, a halogen atom, a hydroxy group, an alkoxy group, an aromatic hydrocarbon group, an aromatic heterocyclic group, and an amino group); R 1 represents a hydrogen atom, an alkyl group, a cycloalkyl group, a haloalkyl group, an aromatic hydrocarbon group, or an aromatic heterocyclic group (the aromatic hydrocarbon group or the aromatic heterocyclic group may have 1 to 5 substituents selected from the group consisting of an alkyl group, a cycloalkyl group, a haloalkyl group, a halogen atom, a hydroxy group, an alkoxy group, an aromatic hydrocarbon group, an aromatic heterocyclic group, and an amino group); and n is an integer from 0 to 2)), wherein the ±-amino group at the amino terminus of the amino acid sequence is linked, via a peptide bond, to the carboxyl group at the carboxyl terminus of the amino acid sequence.
Inventors:
Kanai
Youma Soma
Arai Yusei
Daisuke Sasaki
Yuki Kobayashi
Youma Soma
Arai Yusei
Daisuke Sasaki
Yuki Kobayashi
Application Number:
JP2013061722A
Publication Date:
November 04, 2015
Filing Date:
March 25, 2013
Export Citation:
Assignee:
Japan Science and Technology Agency
International Classes:
C07K7/64; A61K38/00; A61P25/28
Domestic Patent References:
| JP2003503312A | ||||
| JP2003532656A | ||||
| JP11514333A |
Foreign References:
| WO1997021728A1 | ||||
| WO2002074931A1 | ||||
| US6022859 |
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation