アミノ糖含有グルカン、その製造法および利用

Japanese Patent JP5812537

B2

An object of the present invention is to provide a glucosamine-containing glucan, a modified product and a conjugate thereof. The glucosamine-containing glucan of the present invention is a glucosamine-containing glucan wherein the glucan has a plurality of non-reducing ends and at least one glucosamine residue is bound via an ±-1,4-bond to each of two or more non-reducing ends of the branched ±-1,4-glucan, but no glucosamine residue is present at a position other than the non-reducing ends of the branched ±-1,4-glucan, wherein the degree of polymerization of the glucan is 15 or more and 4 x 10 5 or less. Theglucosamine-containingglucan of the present invention can be provided by allowing an ±-glucan phosphorylase to act on an aqueous solution comprising a branched ±-1,4-glucan and glucosamine-1-phosphate.

Takaba Takeshi
Kubo Akiko
Yanase Michiyo

JP2012541754A

November 17, 2015

November 07, 2011

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Ezaki Glico Co., Ltd.

C12P19/26; A61K47/36; A61K48/00; C08B37/00

JPN6012004337; 梅ヶ谷　勇太　他: 'ホスホリラーゼ触媒による末端にグルクロン酸残基を有する分岐型多糖の合成' 高分子学会予稿集 Ｖｏｌ．５９，Ｎｏ．１, 20100511, ｐ．１８１４
JPN6012004339; 梅ヶ谷　勇太　他: 'ホスホリラーゼによる分岐状多糖へのグルクロン酸残基の転移反応' セルロース学会年次大会講演要旨集 Ｖｏｌ．１７ｔｈ, 20100701, ｐ．４４
JPN6012004341; 門川　淳一　他: '酵素的グルクロン酸残基の転移反応を利用したアニオン性多分岐多糖の合成' 高分子学会予稿集 Ｖｏｌ．５９　Ｎｏ．２, 20100901, ｐ．４８７５
JPN6014040031; Ｎａｗａｊｉ　ｅｔ　ａｌ．: Ｃａｒｂｏｈｙｄｒａｔｅ　Ｒｅｓｅａｒｃｈ Ｖｏｌ．３４３, ｐ．２６９２-２６９６（２００８）

Hidesaku Yamamoto
Natsuki Morishita

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