Title:
ブルトン型チロシンキナーゼの阻害剤
Document Type and Number:
Japanese Patent JP5823518
Kind Code:
B2
Abstract:
This application discloses 6-(2-Hydroxymethyl-phenyl)-2-methyl-2H-pyridazin-3-one derivatives according to generic Formula I: wherein, variables X, R, and Y4, are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
Inventors:
Stephen Joseph, Basel
Billedeau, Roland Jay
Brotherton-Place, Christine Yee
Philoznia, Faribose
Gabriel, Stephen Dreams
Han, Xiao Chun
Hilgenkamp, Ramona
James-Figueroa, Saul
Coser, burent
Lopez-Tapier, Francisco Javier
Lowe, Yang
Lujechawski, Lucha
Owens, Timothy Dee
Tan, Jenny
Wov Crich, Peter Michael
Billedeau, Roland Jay
Brotherton-Place, Christine Yee
Philoznia, Faribose
Gabriel, Stephen Dreams
Han, Xiao Chun
Hilgenkamp, Ramona
James-Figueroa, Saul
Coser, burent
Lopez-Tapier, Francisco Javier
Lowe, Yang
Lujechawski, Lucha
Owens, Timothy Dee
Tan, Jenny
Wov Crich, Peter Michael
Application Number:
JP2013523591A
Publication Date:
November 25, 2015
Filing Date:
August 09, 2011
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D237/32; A61K31/502; A61K31/5377; A61K31/541; A61P11/06; A61P19/02; A61P29/00; A61P37/00; A61P43/00; C07D401/14; C07D403/14; C07D405/14; C07D487/04; C07D487/08; C07D487/10; C07D491/107
Domestic Patent References:
| JP2012519200A | ||||
| JP2012524748A | ||||
| JP2014520079A | ||||
| JP2013536862A |
Foreign References:
| WO2009098144A1 | ||||
| WO2009053269A1 | ||||
| WO2009156284A1 | ||||
| WO2010000633A1 |
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Takumi Terachi
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Takumi Terachi