Title:
抗ＣＤ３０ｖｃ−ＰＡＢ−ＭＭＡＥ抗体−薬物コンジュゲートのウィークリー投与計画
Document Type and Number:
Japanese Patent JP5823874
Kind Code:
B2
Abstract:
Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula I.:or a pharmaceutically acceptable salt thereof;wherein:mAb is an anti-CD30 antibody unit,S is a sulfur atom of the antibody,A- is a Stretcher unit, andp is from about 3 to about 5.
More Like This:
Inventors:
Eric, Shivers
Kennedy, Dana
Eel, Nathan
Sun, Michael
Kennedy, Dana
Eel, Nathan
Sun, Michael
Application Number:
JP2011545458A
Publication Date:
November 25, 2015
Filing Date:
January 08, 2010
Export Citation:
Assignee:
Seattle Genetics, Incorporated
International Classes:
A61K39/395; A61P35/02
Domestic Patent References:
| JP2008521828A | ||||
| JP2008500961A |
Foreign References:
| US20070166309 |
Other References:
BARTLETT,A PHASE 1 MULTIDOSE STUDY OF SGN-30 IMMUNOTHERAPY IN PATIENTS WITH REFRACTORY OR RECURRENT 以下備考,BLOOD,2008年 2月15日,V111,P1848-1854,CD30+ HEMATOLOGIC MALIGNANCIES
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka