Title:
乱用の可能性が低いＰＥＧ化オピオイド
Document Type and Number:
Japanese Patent JP5827123
Kind Code:
B2
Abstract:
The invention provides opioid agonists, in particular morphine and codeine, covalently bound to a water-soluble oligomer, namely a polyethylene glycol (PEG) oligomer having reduced potential for substance abuse and uses thereof. The compounds of the invention possess altered pharmacokinetic profiles relative to the opioid agonists alone, but are not subject to the risk of physical tampering that allows for the recovery and abuse of the opioid agonist associated with certain alternative delivery formulations.
Inventors:
Jude-Fishburn, Sea. Simon
Liery, Timothy A.
The Carrias, Albert
Gartha Hani, Ima
Liery, Timothy A.
The Carrias, Albert
Gartha Hani, Ima
Application Number:
JP2011526872A
Publication Date:
December 02, 2015
Filing Date:
September 16, 2009
Export Citation:
Assignee:
Wells Fargo Bank National Association
International Classes:
C07D489/02; A61K31/135; A61K31/4468; A61K31/485; A61P25/36; A61P43/00; C07D211/58
Domestic Patent References:
| JP5420427B2 | ||||
| JP2006520392A | ||||
| JP2004536811A | ||||
| JP60149589A | ||||
| JP2005506351A | ||||
| JP2007514761A | ||||
| JP2002522463A | ||||
| JP2003511357A | ||||
| JP2011515495A |
Foreign References:
| WO2008057579A1 | ||||
| WO2008036980A1 | ||||
| WO2006126529A1 |
Other References:
FRENSCH K,OLIGO ETHYLENE GLYCOL ETHERS OF MORPHINE,LIEBIGS ANNALEN DER CHEMIE,ドイツ,VERLAG CHEMIE GMBH,1979年 1月 1日,N12,P2118-2120
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Tetrahedron Letters,Vol.25, No.31,p.3335-3338 (1984).
Journal of Chromatography,Vol.331, No.1,p.11-21 (1985).
Journal of Chromatography B: Biomedical Applications,Vol.652, No.2,p.137-147 (1994).
Journal of Medicinal Chemistry,Vol.29, No.5,p.874-876 (1986).
Journal of Medicinal Chemistry,Vol.25, No.7,p.847-849 (1982).
Neuroscience,Vol.15, No.4,p.1247-1253 (1985).
Polymer Degradation and Stability,Vol.80, No.2,p.199-202 (2003).
Tetrahedron Letters,Vol.25, No.31,p.3335-3338 (1984).
Journal of Chromatography,Vol.331, No.1,p.11-21 (1985).
Journal of Chromatography B: Biomedical Applications,Vol.652, No.2,p.137-147 (1994).
Journal of Medicinal Chemistry,Vol.29, No.5,p.874-876 (1986).
Journal of Medicinal Chemistry,Vol.25, No.7,p.847-849 (1982).
Neuroscience,Vol.15, No.4,p.1247-1253 (1985).
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto