Title:
ビスアシル化ヒドロキシルアミン誘導体
Document Type and Number:
Japanese Patent JP5832447
Kind Code:
B2
Abstract:
The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.
Inventors:
Toscano, John Pea.
Sutton, art
Kalish, Vincent Jay.
Brookfield, frederick, arthur
Courtney, stephan martin
Frost, lisa marie
Sutton, art
Kalish, Vincent Jay.
Brookfield, frederick, arthur
Courtney, stephan martin
Frost, lisa marie
Application Number:
JP2012543211A
Publication Date:
December 16, 2015
Filing Date:
December 07, 2010
Export Citation:
Assignee:
THE JOHNS HOPKINS UNIVERSITY
Cardioxol Pharmaceuticals, Inc.
Cardioxol Pharmaceuticals, Inc.
International Classes:
A61K31/215; C07C259/06; A61K31/235; A61K31/27; A61K31/343; A61K31/351; A61K31/381; A61K31/401; A61K31/4406; A61K31/495; A61K31/5375; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P35/00; C07C259/10; C07C271/08; C07C311/51; C07C311/53; C07C317/14; C07D207/16; C07D213/40; C07D213/71; C07D295/20; C07D307/82; C07D309/12; C07D333/34
Foreign References:
| US4405357 | ||||
| US3498967 | ||||
| GB1258792B | ||||
| WO1998029408A1 |
Other References:
Heywood, Basil J.; Leeds, William G.,Herbicidal carbamates―benzenesulphonylcarbamates,Journal of the Science of Food and Agriculture,1968年,V19 Supplement S1,P3-7
LEE JEEWOO,Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,ELSEVIER SCIENCE,2004年 5月 3日,V14 N9,P2291-2297
OTTO NEUNHOEFFER,LIEBIGS ANNALEN DER CHEMIE,1970年 1月29日,V736,P100-109
BYEONG HYO KIM,INDIUM MEDIATED REDUCTIVE ACYLATIONS OF NITROARENES TOWARDS N,O-DIACYLATED N-ARYLHYDROXYLAMINES,SYNTHETIC COMMUNICATIONS,TAYLOR AND FRANCIS GROUP,2001年 1月 1日,V31 N23,P3577-3586
TOMAZIC A,SYNTHESES OF SOME AZINYLHYDROXYLAMINES(1),JOURNAL OF HETEROCYCLIC CHEMISTRY,米国,WILEY-BLACKWELL PUBLISHING, INC,1979年 7月 1日,V16 N5,P861-864
YAGODINA O V,Acylation and oxidation of 4-chloro-6-(hydroxyamino)pyrimidines. Synthesis of 4-chloro-6-nitro(nitroso)pyrimidines,CHEMISTRY OF HETEROCYCLIC COMPOUNDS,1988年 6月 9日,V25,P908-913
MILEWSKA,OXIDATION OF AMINO ACIDS. IV* REACTION OF DIBENZOYL PEROXIDE WITH ω-AMINO ACID ESTERS,AUSTRALIAN JOURNAL OF CHEMISTRY,AU,1987年 1月 1日,V40 N11,P1919-1922
STANLEY C. BELL,A NEW SYNTHESIS OF 7-CHLORO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE 4-OXIDE,JOURNAL OF HETEROCYCLIC CHEMISTRY,1967年12月 1日,V4 N4,P647-649
JYH MING LIN,AN INVESTIGATION OF THE INTRAMOLECULAR ENE REACTION OF N-ACYL IMINES,THE JOURNAL OF ORGANIC CHEMISTRY,1986年 1月 1日,V51 N2,P167-174
PEDRO P O SANTOS,SELECTIVE O-ACYLATION OF AROMATIC HYDROXYLAMINES BY 2-ACYLIMIDAZOLIUM 以下備考,TETRAHEDRON LETTERS,1993年 3月23日,V34 N23,P3793-3796,AND 2-ACYLBENZIMIDAZOLIUM SALTS
DAVID J. ANDERSON,NOVEL SYNTHESIS OF PYRIDO[1,2-A]BENZIMIDAZOLES VIA REACTION OF N-ACYL ARYLHYDROXYLAMINES WITH PYRIDINE,JOURNAL OF HETEROCYCLIC CHEMISTRY,1986年 7月 1日,V23 N4,P1091-1094
BASKAKOV,BIOLOGICHESKI AKTIVNYKH SOEDINENII,1968年 1月 1日,V71,P96-100
Boyland, E.; Nery, R.,The oxidation of hydroxamic acids,Journal of the Chemical Society [Section] C: Organic ,1966年,(3),354-8
LOUIS F. FIESER,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,1940年 7月 1日,V62 N7,P1640-1645
LEE M J C,PRODRUGS OF NITROXYL AS INHIBITORS OF ALDEHYDE DEHYDROGENASE,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,1992年 1月 1日,V35,P3648-3652
KLAUS REHSE,HYDROXYLAMINE DERIVATIVES,ARCHIV DER PHARMAZIE,1998年 4月24日,V331,P365-367
LEE JEEWOO,Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,ELSEVIER SCIENCE,2004年 5月 3日,V14 N9,P2291-2297
OTTO NEUNHOEFFER,LIEBIGS ANNALEN DER CHEMIE,1970年 1月29日,V736,P100-109
BYEONG HYO KIM,INDIUM MEDIATED REDUCTIVE ACYLATIONS OF NITROARENES TOWARDS N,O-DIACYLATED N-ARYLHYDROXYLAMINES,SYNTHETIC COMMUNICATIONS,TAYLOR AND FRANCIS GROUP,2001年 1月 1日,V31 N23,P3577-3586
TOMAZIC A,SYNTHESES OF SOME AZINYLHYDROXYLAMINES(1),JOURNAL OF HETEROCYCLIC CHEMISTRY,米国,WILEY-BLACKWELL PUBLISHING, INC,1979年 7月 1日,V16 N5,P861-864
YAGODINA O V,Acylation and oxidation of 4-chloro-6-(hydroxyamino)pyrimidines. Synthesis of 4-chloro-6-nitro(nitroso)pyrimidines,CHEMISTRY OF HETEROCYCLIC COMPOUNDS,1988年 6月 9日,V25,P908-913
MILEWSKA,OXIDATION OF AMINO ACIDS. IV* REACTION OF DIBENZOYL PEROXIDE WITH ω-AMINO ACID ESTERS,AUSTRALIAN JOURNAL OF CHEMISTRY,AU,1987年 1月 1日,V40 N11,P1919-1922
STANLEY C. BELL,A NEW SYNTHESIS OF 7-CHLORO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE 4-OXIDE,JOURNAL OF HETEROCYCLIC CHEMISTRY,1967年12月 1日,V4 N4,P647-649
JYH MING LIN,AN INVESTIGATION OF THE INTRAMOLECULAR ENE REACTION OF N-ACYL IMINES,THE JOURNAL OF ORGANIC CHEMISTRY,1986年 1月 1日,V51 N2,P167-174
PEDRO P O SANTOS,SELECTIVE O-ACYLATION OF AROMATIC HYDROXYLAMINES BY 2-ACYLIMIDAZOLIUM 以下備考,TETRAHEDRON LETTERS,1993年 3月23日,V34 N23,P3793-3796,AND 2-ACYLBENZIMIDAZOLIUM SALTS
DAVID J. ANDERSON,NOVEL SYNTHESIS OF PYRIDO[1,2-A]BENZIMIDAZOLES VIA REACTION OF N-ACYL ARYLHYDROXYLAMINES WITH PYRIDINE,JOURNAL OF HETEROCYCLIC CHEMISTRY,1986年 7月 1日,V23 N4,P1091-1094
BASKAKOV,BIOLOGICHESKI AKTIVNYKH SOEDINENII,1968年 1月 1日,V71,P96-100
Boyland, E.; Nery, R.,The oxidation of hydroxamic acids,Journal of the Chemical Society [Section] C: Organic ,1966年,(3),354-8
LOUIS F. FIESER,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,1940年 7月 1日,V62 N7,P1640-1645
LEE M J C,PRODRUGS OF NITROXYL AS INHIBITORS OF ALDEHYDE DEHYDROGENASE,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,1992年 1月 1日,V35,P3648-3652
KLAUS REHSE,HYDROXYLAMINE DERIVATIVES,ARCHIV DER PHARMAZIE,1998年 4月24日,V331,P365-367
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Mami Hino
Kyoei Sugiyama
Yasuhito Suzuki
Norio Omori
Mami Hino
Kyoei Sugiyama
Yasuhito Suzuki
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