Title:
ＴＲＫキナーゼ阻害剤としてのマクロ環化合物
Document Type and Number:
Japanese Patent JP5832527
Kind Code:
B2
Abstract:
The present invention relates with a process for preparing compounds of Formula I:and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R, R, R, R, and Z are as defined herein, and which are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases;intermediates of formula IIused in the preparation of compounds of formula I and the compound for use in the treatment of the diseases mentioned above of the following formula:
Inventors:
Andrews, Stephen Wade
Condroski, Kevin Ronald
Hearth, Julia
Cian, Youton
Korakawski, Gabriel Earl.
Seo, John Bob
Yang, Hong-Won
Chao, Chiang
Condroski, Kevin Ronald
Hearth, Julia
Cian, Youton
Korakawski, Gabriel Earl.
Seo, John Bob
Yang, Hong-Won
Chao, Chiang
Application Number:
JP2013511239A
Publication Date:
December 16, 2015
Filing Date:
May 13, 2011
Export Citation:
Assignee:
VentiRx Pharmaceuticals,Inc.
International Classes:
C07D471/22; A61K31/519; A61P25/00; A61P25/04; A61P29/00; A61P33/02; A61P35/00; A61P43/00; C07D498/22
Domestic Patent References:
| JP2009541242A | ||||
| JP2007504276A | ||||
| JP2007514712A | ||||
| JP2008523034A |
Foreign References:
| WO2010048314A1 | ||||
| WO2008155421A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita