Title:
ブルトン型チロシンキナーゼの阻害剤
Document Type and Number:
Japanese Patent JP5832664
Kind Code:
B2
Abstract:
This application discloses compounds according to generic Formula I: wherein the variables are defined as described herein, and which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
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Inventors:
Brotherton-Place, Christine
Lopez-Tapier, Francisco Hubbie
Low, Yen
Lopez-Tapier, Francisco Hubbie
Low, Yen
Application Number:
JP2014545248A
Publication Date:
December 16, 2015
Filing Date:
December 06, 2012
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D401/14; A61K31/502; A61K31/5025; A61K31/5377; A61P29/00; A61P37/06; A61P43/00; C07D471/04; C07D487/04
Domestic Patent References:
| JP2014532715A |
Foreign References:
| WO2010006947A1 | ||||
| WO2010100070A1 | ||||
| WO2010006970A1 | ||||
| WO2009137596A1 | ||||
| WO2008033834A1 |
Attorney, Agent or Firm:
Patent business corporation Tsukuni
Hajime Tsukuni
Yasuo Yanagibashi
Toshio Miyake
Akio Shibata
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Atsushi Shiomi
Hajime Tsukuni
Yasuo Yanagibashi
Toshio Miyake
Akio Shibata
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Atsushi Shiomi
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