Title:
診断方法のためのＩＧＦＢＰ−４断片の検出
Document Type and Number:
Japanese Patent JP5840605
Kind Code:
B2
Abstract:
Disclosed is a method for detecting IGFBP-4 (Insulin-like Growth Factor Binding Protein-4) fragments. The method uses antibodies or antigen binding fragments that specifically recognize epitopes on IGFBP-4 fragments. The IGFBP-4 fragments include the N-terminal and C-terminal fragments resulting from PAPP-A dependent cleavage of IGFBP-4. Assay and diagnostic methods using detection of IGFBP-4 fragments are also disclosed.
Inventors:
Katuluka, Alexei G.
Post Nikov, Alexander Bee.
Soloviewa, Tatiana Ai.
Karytonov, Alexey Ve.
Post Nikov, Alexander Bee.
Soloviewa, Tatiana Ai.
Karytonov, Alexey Ve.
Application Number:
JP2012516812A
Publication Date:
January 06, 2016
Filing Date:
June 29, 2010
Export Citation:
Assignee:
HYTEST LTD.
International Classes:
C07K16/18; G01N33/53; G01N33/574
Domestic Patent References:
| JP2004536600A | ||||
| JP2002511748A |
Foreign References:
| WO2009059972A1 |
Other References:
Clinical Chemistry,2007年,Vol.53, No.5,p.947-954
The Journal of Clinical Endocrinology & Metabolism,2002年,Vol.87, No.11,p.5235-5240
医学のあゆみ,2008年,Vol.224, No.5,p.385-388
Clinical Biochemistry,2002年,Vol.35,p.531-538
Journal of Endocrinology,2003年,Vol.178,p.177-193
The Journal of Clinical Endocrinology & Metabolism,2002年,Vol.87, No.11,p.5235-5240
医学のあゆみ,2008年,Vol.224, No.5,p.385-388
Clinical Biochemistry,2002年,Vol.35,p.531-538
Journal of Endocrinology,2003年,Vol.178,p.177-193
Attorney, Agent or Firm:
Junzo Watanabe