Title:
ＣＤ２０抗体およびその使用
Document Type and Number:
Japanese Patent JP5841072
Kind Code:
B2
Abstract:
CD20 is a transmembrane protein of the tetra-spanin family expressed on the surface of B-cells from peripheral blood as well as lymphoid tissues. CD20 expression persists from the early pre-B cell stage until the plasma cell differentiation stage. In addition to expression in normal B-cells, CD20 is expressed in B-cell derived malignancies such as non-Hodgkin's lymphoma (NHL) and B-cell chronic lymphocytic leukemia (CLL). The present invention includes anti-CD20 antibodies and antigen-binding fragments thereof comprising a light chain variable region and a heavy chain variable region, wherein the CDR-L1, CDR-L2, and CDR-L3 of said light chain variable region comprise the amino acid sequences of SEQ ID NOs: 17-19, respectively, and wherein the CDR-H1, CDR-H2, and CDR-H3 of said heavy chain variable region comprise the amino acid sequences of SEQ ID NOs: 20-22, respectively.
Inventors:
Decker, Jutta
Louis, Linkyun
Park, Peter You
Louis, Linkyun
Park, Peter You
Application Number:
JP2012552986A
Publication Date:
January 06, 2016
Filing Date:
February 10, 2011
Export Citation:
Assignee:
Immunogen Incorporated
International Classes:
C12N15/09; C07K16/28
Foreign References:
| US20040093621 | ||||
| US20060018911 | ||||
| US20040167319 | ||||
| WO2008156713A2 |
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Hirose Shinobu
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Hirose Shinobu
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