Title:
５’−メチルチオアデノシンホスホリラーゼ及びヌクレオシダーゼの３−ヒドロキシピロリジン阻害剤
Document Type and Number:
Japanese Patent JP5861243
Kind Code:
B2
Abstract:
The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (1) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to inhibit 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds.
Inventors:
Evans, Gary Brian
Long show, alistair ian
Shram, Baan El.
Tyler, peter, charles
Long show, alistair ian
Shram, Baan El.
Tyler, peter, charles
Application Number:
JP2012520557A
Publication Date:
February 16, 2016
Filing Date:
July 16, 2010
Export Citation:
Assignee:
Albert Einstein College of Medicine of Yeshiva University
International Classes:
C07D487/04; A61K31/519; A61P31/04; A61P35/00; A61P43/00
Domestic Patent References:
| JP2006516615A | ||||
| JP2006501239A | ||||
| JP2008508287A | ||||
| JP2005527544A |
Foreign References:
| WO2009082247A1 | ||||
| WO2007097648A1 | ||||
| WO2007097647A1 | ||||
| WO2007069923A1 | ||||
| WO2008079028A1 | ||||
| WO2006123953A1 |
Other References:
Dalian Gongye Daxue Xueba,2008年,27(1),10-14
Biochemistry,2006年,45(43),12929-12941
Journal of Medicinal Chemistry ,2005年,48(14),4679-4689
Journal of Biological Chemistry ,2005年,280(18),18265-18273
Biochemistry,2006年,45(43),12929-12941
Journal of Medicinal Chemistry ,2005年,48(14),4679-4689
Journal of Biological Chemistry ,2005年,280(18),18265-18273
Attorney, Agent or Firm:
Ikeda adult
Kazuhiro Yamaguchi
Masakazu Noda
Kazuhiro Yamaguchi
Masakazu Noda