Title:
コレステロールを隔離するのに適したナノ構造体
Document Type and Number:
Japanese Patent JP5866401
Kind Code:
B2
Abstract:
Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids. In some embodiments, the structures, when introduced into a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels.
Inventors:
Chad A. Milkin
Seed Shadow Saxton
David A. Gil Johann
Weston Daniel
Seed Shadow Saxton
David A. Gil Johann
Weston Daniel
Application Number:
JP2014094559A
Publication Date:
February 17, 2016
Filing Date:
May 01, 2014
Export Citation:
Assignee:
Northwestern, University
International Classes:
A61K9/51; A61K38/00; A61K47/44; A61K49/00; A61P3/00; A61P3/06; A61P7/04; A61P9/00; A61P25/00; A61P29/00; A61P35/00
Other References:
Nikolov, V. et al,Bias-dependent admittance inhybrid bilayer membranes,Langmuir,2006年,Vol.22, No.17,p.7156-7158
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita