Title:
細胞周期の不定期の活性化に関連する神経変性障害または疾患の治療に有用なＣＤＫ４／ＣＤＫ６阻害剤をコードする誘導性遺伝子を含有するベクター
Document Type and Number:
Japanese Patent JP5869884
Kind Code:
B2
Abstract:
Described is vector or a mixture of at least two vectors comprising (a) a nucleic acid molecule encoding a protein of the INK4 family under the control of a neuron-specific promoter; and (b) a nucleic acid molecule encoding a transactivator protein that is capable of binding to and activating the neuron-specific promoter of (a) useful for treating neurodegenerative disorders. These vectors can be transferred into cells where they will exert a protective function to (i) prevent cell death or to (ii) slow down progression of cell death. These vectors can be used in therapeutic applications to prevent neurodegenerative disorders or to slow down their progression with therapeutic efficacy.
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Inventors:
Arento, thomas
Uberham, Uwe
Uberham, Uwe
Application Number:
JP2011548607A
Publication Date:
February 24, 2016
Filing Date:
February 04, 2010
Export Citation:
Assignee:
Unibergate Tate Leipzig
International Classes:
C12N15/09; A61K31/7088; A61K48/00; A61P25/00; A61P25/28; A61P43/00
Other References:
Oncogene,1997年,Vol.15,p.2037-2048
UEBERHAM U,EXPRESSION OF P16INK4A PROTEIN PROTECTS DIFFERENTIATED CELLS FROM APOPTOSIS,SOCIETY FOR NEUROSCIENCE ABSTRACTS,2001年,V27 N2,P2318, 872.3
European Journal of Neuroscience,2005年,Vol.22,p.50-64
The EMBO Journal,1996年,Vol.15, No.1,p.46-54
Journal of Cellular and Molecular Medicine,2008年,Vol.12, No.2,p.622-638
UEBERHAM U,EXPRESSION OF P16INK4A PROTEIN PROTECTS DIFFERENTIATED CELLS FROM APOPTOSIS,SOCIETY FOR NEUROSCIENCE ABSTRACTS,2001年,V27 N2,P2318, 872.3
European Journal of Neuroscience,2005年,Vol.22,p.50-64
The EMBO Journal,1996年,Vol.15, No.1,p.46-54
Journal of Cellular and Molecular Medicine,2008年,Vol.12, No.2,p.622-638
Attorney, Agent or Firm:
Shinki Global IP Patent Corporation