Title:
増強された抗腫瘍効果を有する改変パルボウイルス
Document Type and Number:
Japanese Patent JP5873863
Kind Code:
B2
Abstract:
Described are parvovirus variants derived, e.g., from H-1PV, showing higher anti-tumour potential compared to the wild type parvovirus, wherein said variant is characterized by (a) an amino acid substitution, alteration or addition, preferably substitution at position Lys96 of NS-2 and/or position Leu103 of NS-2 (together with a amino acid substituion at position Tyr595 of NS-1 in the latter case), or (b) an in-frame deletion in the parvovirus genome, preferably a deletion resulting in a large amino acid deletion in both the central part (aa 96-133) of NS-2 and the C-terminal part (aa 587-624) of NS-1. The present invention also relates to the use of said parvovirus variants for cancer therapy.
Inventors:
Salome, natalie
Dinzart, Christiane
Michel, Nadine
Rommerlele, jean
Dinzart, Christiane
Michel, Nadine
Rommerlele, jean
Application Number:
JP2013514600A
Publication Date:
March 01, 2016
Filing Date:
June 17, 2011
Export Citation:
Assignee:
DEUTSCHES KREBSFORSCHUNGSZENTRUM
International Classes:
A61K35/76; A61K35/768; A61P1/16; A61P1/18; A61P15/00; A61P35/00; A61P35/02; C12N7/00; C12N15/09
Other References:
JOURNAL OF VIROLOGY, vol.78, no.19, 2004, pages 10674-84
JOURNAL OF VIROLOGY, vol.69, no.7,1995, pages 4538-43
JOURNAL OF VIROLOGY, vol.77, no.23, 2003, pages 12466-78
JOURNAL OF VIROLOGY, vol.69, no.7,1995, pages 4538-43
JOURNAL OF VIROLOGY, vol.77, no.23, 2003, pages 12466-78
Attorney, Agent or Firm:
Patent business corporation r&c
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