Title:
グルタチオンアルキルエステル同位体置換体および反応性代謝物の検出方法
Document Type and Number:
Japanese Patent JP5878170
Kind Code:
B2
Abstract:
[Problem] To provide a novel isotope-labeled compound that can be used as a trapping agent and that is useful for picking out drug-candidate compounds that produce reactive metabolites. [Solution] Provided is a glutathione alkylester isotopologue represented by general formula (1). In formula (1), R1 represents a linear or branched alkoxy group in which at least one of carbon, oxygen, and hydrogen atoms contained therein is isotope-labeled and which has 1 to 8 carbon atoms or a cycloalkoxy group in which at least one of carbon, oxygen, and hydrogen atoms contained therein is isotope-labeled and which has 3 to 8 carbon atoms.
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Inventors:
Toshikazu Yamaoka
Application Number:
JP2013516202A
Publication Date:
March 09, 2016
Filing Date:
May 21, 2012
Export Citation:
Assignee:
Kyorin Pharmaceutical Co., Ltd.
International Classes:
C07K5/037; C07B59/00; G01N27/62
Foreign References:
| WO2006012154A1 | 2006-02-02 |
Other References:
JPN6012035700; ＭＵＴＬＩＢ Ａ．， ｅｔ ａｌ．: Ｒａｐｉｄ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ ｉｎ Ｍａｓｓ Ｓｐｅｃｔｒｏｍｅｔｒｙ Ｖｏｌ．１９, 2005, ｐ．３４８２-３４９２
JPN6012035702; ＹＡＮ Ｚ．， ｅｔ ａｌ．: Ａｎａｌｙｔｉｃａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７６， Ｎｏ．２３, 2004, ｐ．６８３５-６８４７
JPN6012035704; ＹＡＮ Ｚ．， ｅｔ ａｌ．: Ａｎａｌｙｔｉｃａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７９， Ｎｏ．１１, 2007, ｐ．４２０６-４２１４
JPN6012035702; ＹＡＮ Ｚ．， ｅｔ ａｌ．: Ａｎａｌｙｔｉｃａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７６， Ｎｏ．２３, 2004, ｐ．６８３５-６８４７
JPN6012035704; ＹＡＮ Ｚ．， ｅｔ ａｌ．: Ａｎａｌｙｔｉｃａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７９， Ｎｏ．１１, 2007, ｐ．４２０６-４２１４
Attorney, Agent or Firm:
Mizuno Katsufumi
Masayuki Kishida
Hiroshin Takano
Makoto Ide
Hiroshi Suzawa
Hisamatsu Yosuke
Masayuki Kishida
Hiroshin Takano
Makoto Ide
Hiroshi Suzawa
Hisamatsu Yosuke