高硫酸化コンドロイチン硫酸類の合成方法、高硫酸化コンドロイチン硫酸類、および解析用試薬

Title:

高硫酸化コンドロイチン硫酸類の合成方法、高硫酸化コンドロイチン硫酸類、および解析用試薬

Document Type and Number:

Japanese Patent JP5885136

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To provide a method for synthesizing highly sulfated chondroitin sulfates.SOLUTION: The method for synthesizing highly sulfated chondroitin sulfates includes: a step (A1) of forming A structure of a chondroitin sulfate by making sulfotransferase (C4ST-1) act on the chondroitin; a step (A2) of forming E structure of a chondroitin sulfate by making a sulfotransferase (Ga1NAc4S-6ST) act on the A structure; and a step (A3) of forming triS structure of a chondroitin sulfate by making a sulfotransferase UST act on the E structure.

Inventors:

Nobuo Sugiura

Application Number:

JP2011018629A

Publication Date:

March 15, 2016

Filing Date:

January 31, 2011

Export Citation:

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Assignee:

Aichi Medical University

International Classes:

C12P19/26; A61K49/00; C08B37/08; G01N33/536; G01N33/566

Domestic Patent References:

JP2006223198A
JP2005526740A
JP2003289882A
JP2001061481A
JP2007244398A

Foreign References:

WO2004078969A1

Other References:

Ohtake, Shiori,Recognition of Sulfation Pattern of Chondroitin Sulfate by Uronosyl 2-O-Sulfotransferase,Journal of Biological Chemistry,2005年,280(47),39115-39123
Habuchi,Osami,Sulfation of chondroitin Sulfate and Related Sugar Chains,Trends in Glycoscience and Glycotechnology,2000年,Vol.12,No.67,307-319
Takagaki,Keiichi,Synthesis of chondroitin Sulfate Oligosaccharides Using Enzymeatic Reconstruction,Trends in Glycoscience and Glycotechnology,2000年,Vol.12,No.67,295-306

Attorney, Agent or Firm:

Sakaki Morishita

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