Title:
カドヘリン−１１のＥＣ１ドメインを標的とするヒト化抗体ならびに関連組成物および方法
Document Type and Number:
Japanese Patent JP5886283
Kind Code:
B2
Abstract:
The present invention relates to humanized antibodies that specifically bind an EC1 domain of a mammalian Cadherin-11 protein and compositions ( e.g ., pharmaceutical compositions) comprising such antibodies. The invention also relates to methods for treating Cadherin-11-mediated disorders in a mammalian subject by administering a therapeutically effective amount of a humanized antibody of the invention. Cadherin-11-mediated disorders suitable for treatment by the methods of the invention include inflammatory disorders ( e.g ., inflammatory joint disorders, such as rheumatoid arthritis), fibrosis and cancer.
Inventors:
MacArthur, James, Gee.
Application Number:
JP2013519849A
Publication Date:
March 16, 2016
Filing Date:
July 15, 2011
Export Citation:
Assignee:
Adheron Therapeutics, Incorporated
International Classes:
C12N15/09; A61K39/395; A61P19/02; A61P29/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Foreign References:
| WO2009089062A1 | ||||
| WO2009101059A1 |
Attorney, Agent or Firm:
Yoshinori Hosoda