Title:
インビボでの神経膠芽腫細胞の浸潤を阻害するＣＤ９５活性の中和
Document Type and Number:
Japanese Patent JP5893078
Kind Code:
B2
Abstract:
The present invention relates to methods for treating an individual with high grade glioblastoma multiforme by preventing or disrupting the binding of CD95 to its ligand, CD95L, in vivo, whereupon that neutralization of CD95 activity reduces undesirable glial cell migration and invasion into body tissue.
Inventors:
Ana Martin-Bilalba
Zuzanne Clever
Benedict Wiestler
Peter G. Clammer
Christer Herold-Mende
Ignacio Sancho-Martinez
Zuzanne Clever
Benedict Wiestler
Peter G. Clammer
Christer Herold-Mende
Ignacio Sancho-Martinez
Application Number:
JP2014116401A
Publication Date:
March 23, 2016
Filing Date:
June 05, 2014
Export Citation:
Assignee:
Deutsches Krebsforschungszentrum
Universitaetsklinikum Heidelberg
Universitaetsklinikum Heidelberg
International Classes:
A61K39/395; A61K38/00; A61P35/00
Foreign References:
| WO1996029350A1 | ||||
| WO2004085478A1 |
Other References:
EMBO J,2004年,Vol.23, No.15,p.3175-85
Cell Cycle,2004年,Vol.3, No.10,p.1235-9,e87-91
J Biol Chem,2004年,Vol.279, No.45,p.46742-7
J Neurooncol,2004年,Vol.67, No.1-2,p.29-39
Cell Cycle,2004年,Vol.3, No.10,p.1235-9,e87-91
J Biol Chem,2004年,Vol.279, No.45,p.46742-7
J Neurooncol,2004年,Vol.67, No.1-2,p.29-39
Attorney, Agent or Firm:
Einzel Felix-Reinhard
Shuichi Sumiyoshi
Takuya Kuno
Shuichi Sumiyoshi
Takuya Kuno
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