Title:
カチオン性脂質
Document Type and Number:
Japanese Patent JP5902617
Kind Code:
B2
Abstract:
The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I)
(wherein:
R 1 and R 2 are, the same or different, each (Z)-pentadecenyl, (Z)-hexadecenyl or ( Z )-heptadecenyl, etc,
a and b are, the same or different, each 0 to 3,
m is 1,
the dotted line is a single bond or absent,
X 1 and X 2 are hydrogen atoms, or are combined together to form a single bond or alkylene,
X 4 is absent or is alkylene, etc
X 3 is absent or is alkyl, etc,
Y is absent or anion,
L 3 is a single bond, -CO-O- or -O-CO-
R 3 is hydrogen atoms, alkyl, etc,
L 1 and L 2 are -0-, -CO-O- or -O-CO-) and the like.
Inventors:
Takeyuki Kuboyama
Kimihiro Era
Tomoyuki Naoi
Kimihiro Era
Tomoyuki Naoi
Application Number:
JP2012512924A
Publication Date:
April 13, 2016
Filing Date:
April 28, 2011
Export Citation:
Assignee:
Kyowa Hakko Kirin Co., Ltd.
International Classes:
C07C217/28; A61K9/127; A61K47/18; A61K47/22; A61K48/00; A61P29/00; A61P35/00; C07D207/12
Domestic Patent References:
| JP2006282604A | 2006-10-19 | |||
| JP2006254877A | 2006-09-28 | |||
| JP2000508642A | 2000-07-11 | |||
| JP2006282604A | 2006-10-19 | |||
| JP2006254877A | 2006-09-28 | |||
| JP2000508642A | 2000-07-11 |
Foreign References:
| WO2010042877A1 | 2010-04-15 | |||
| WO2009132131A1 | 2009-10-29 | |||
| WO2010054406A1 | 2010-05-14 | |||
| WO2010054401A1 | 2010-05-14 | |||
| WO2011000107A1 | 2011-01-06 | |||
| WO2011136368A1 | 2011-11-03 |