Title:
２−アリールベンゾフラン−７−カルボキサミド系化合物、その製造方法および用途
Document Type and Number:
Japanese Patent JP5926821
Kind Code:
B2
Abstract:
Provided in the present invention are a 2-arylbenzofuran-7-formamide compound as shown in general formula I or a pharmacologically or physiologically acceptable salt thereof, a preparation method thereof and use thereof in preparing anti-tumour drugs, wherein R 1 and R 2 are each independently hydrogen, straight or branched chained C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl or saturated 5- or 6-membered heterocyclyl containing oxygen or nitrogen; or R 1 and R 2 together with N form an unsubstituted or substituted saturated 5- or 6-membered heterocyclyl containing at least one heteroatom, wherein the heteroatom is O, N and S, the substituent is a methyl on N; R 3 is a hydrogen atom or a chlorine atom; R 4 is a hydrogen atom or a fluorine atom; X is CH, CF or N; and Y is CH, CF or N.
Inventors:
Yang, Chunhao
Miao, Tse Hong
Din, Jean
One, Men
Hye, Jin Su
Tan, Chun
Chen, Yi
Miao, Tse Hong
Din, Jean
One, Men
Hye, Jin Su
Tan, Chun
Chen, Yi
Application Number:
JP2014555927A
Publication Date:
May 25, 2016
Filing Date:
January 14, 2013
Export Citation:
Assignee:
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
Cisen Pharmaceutical Co., Ltd.
Cisen Pharmaceutical Co., Ltd.
International Classes:
C07D307/82; A61K31/343; A61K31/4025; A61K31/443; A61K31/4525; A61K31/496; A61K31/5377; A61K31/541; A61K31/551; A61P29/00; A61P35/00; A61P43/00; C07D405/04; C07D405/10; C07D405/12
Domestic Patent References:
| JP2011511078A | ||||
| JP2009535427A | ||||
| JP2002528531A | ||||
| JP2003532709A | ||||
| JP2002515488A | ||||
| JP2008513538A |
Foreign References:
| CN102627620A |
Other References:
Bull. Korean Chem. Soc.,2012年,33,1147-1153
Attorney, Agent or Firm:
Kiyoji Kuzuwa
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