Title:
ＰＥＲＫ阻害剤としての新規なＮ（２，３−ジヒドロ−１Ｈ−ピロロ［２，３−ｂ］ピリジン−５−イル）−４−キナゾリンアミン誘導体およびＮ−（２，３−ジヒドロ−１Ｈ−インドール−５−イル）−４−キナゾリンアミン誘導体
Document Type and Number:
Japanese Patent JP6268276
Kind Code:
B2
Abstract:
The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and A have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors of PERK. The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
Inventors:
Stansfield, Ian
Rigny, Yannick, Aime, Eddie
Unbrad, natalie, claudi, isabelle
Bersel, Matthias, Luc, Aime
Rigny, Yannick, Aime, Eddie
Unbrad, natalie, claudi, isabelle
Bersel, Matthias, Luc, Aime
Application Number:
JP2016505782A
Publication Date:
January 24, 2018
Filing Date:
March 31, 2014
Export Citation:
Assignee:
Janssen Pharmaceuticals N.B.
International Classes:
C07D401/14; A61K31/517; A61K31/5377; A61P3/04; A61P3/10; A61P9/00; A61P9/10; A61P25/00; A61P27/02; A61P29/00; A61P31/12; A61P35/00; C07D403/12; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D471/04; C07D491/056
Domestic Patent References:
| JP2013534902A |
Foreign References:
| US20110288083 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Junko Kobayashi
Norio Omori
Uetake Yukiko
Yasuhito Suzuki
Junko Kobayashi
Norio Omori
Uetake Yukiko
Yasuhito Suzuki