Title:
タウ凝集阻害剤
Document Type and Number:
Japanese Patent JP6313750
Kind Code:
B2
Abstract:
Provided is a tau aggregation inhibitor which can sufficiently inhibit a tau protein from aggregating in cells. The inhibitor includes a 4-substituted catechol structure compound, having, at position 4 of its catechol ring, an electron-donating substituent R other than a hydrocarbon group, or a salt thereof The 4-substituted catechol structure compound is preferably 4-aminocatechol or 1,2,4-benzenetriol. Examples of tauopathies to which this inhibitor is applicable include AD, Down's syndrome, frontotemporal dementia, cotricobasal degeneration (CBD) and progressive supranuclear palsy (PSP).
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Inventors:
Tomohiro Miyasaka
Hachiro Sugimoto
Riki Tokimi
Yuki Niizaki
Yohei Oe
Tetsuo Ota
Akihiko Takashima
Yoshiyuki Soeda
Yasuo Ihara
Inoue Zen Ladies
Hachiro Sugimoto
Riki Tokimi
Yuki Niizaki
Yohei Oe
Tetsuo Ota
Akihiko Takashima
Yoshiyuki Soeda
Yasuo Ihara
Inoue Zen Ladies
Application Number:
JP2015509918A
Publication Date:
April 18, 2018
Filing Date:
April 02, 2014
Export Citation:
Assignee:
School corporation Doshisha
National Institute for Longevity Research
National Institute for Longevity Research
International Classes:
A61K31/136; A61K31/05; A61K31/085; A61K31/11; A61K31/5375; A61P25/00; A61P25/28; A61P43/00
Domestic Patent References:
| JP2012508740A | ||||
| JP2003532634A |
Foreign References:
| WO2009003147A1 |
Other References:
Can.J.Chem.,2012年,90,p.865-873
Attorney, Agent or Firm:
Maeda patent office