Title:
レチノイド受容体に選択的な経路に関する方法および組成物
Document Type and Number:
Japanese Patent JP6375340
Kind Code:
B2
Abstract:
Provided herein are methods and compositions related to a retinoid receptor-selective pathway. As described herein, this pathway can be targeted to manipulate a tumor microenviroment. For example, the methods and compositions described herein can be used to induce apoptosis in a cancer cell. Further, the compositions described herein, including Sulindac and analogs thereof, can be used to target this pathway for the treatment or prevention of cancer in human patients.
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Inventors:
Jean, Xiao-Kun
Su, Inn
Joe
Riu, Wen
Hoang, Pay-Chiang
Su, Inn
Joe
Riu, Wen
Hoang, Pay-Chiang
Application Number:
JP2016132716A
Publication Date:
August 15, 2018
Filing Date:
July 04, 2016
Export Citation:
Assignee:
Sanford-Burnham Medical Research Institute
International Classes:
C07C57/60; A61K31/192; A61P35/00; A61P43/00; C07C321/28
Domestic Patent References:
| JP2005247807A |
Other References:
Biochim. Biophys. Acta,1999年 6月28日,Vol.1428,No.1,P.68-76
J. Med. Chem.,2008年 8月28日,Vol.51,No.16,p.4911-4919
J. Med. Chem.,2008年 8月28日,Vol.51,No.16,p.4911-4919
Attorney, Agent or Firm:
Fujimoto Partners Corporation