Title:
癌を治療するための、ＮＩＫ阻害剤としての３−（２−アミノピリミジン−４−イル）−５−（３−ヒドロキシプロピニル）−１Ｈ−ピロロ［２，３−Ｃ］ピリジン誘導体
Document Type and Number:
Japanese Patent JP6389511
Kind Code:
B2
Abstract:
The present invention relates to compounds of formula (I) which are inhibitors of NF-KB-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
Inventors:
Hind, George
Price, Stefan
Klagosky, Janus
Macleod, column
Man, samuel edward
Panchal, Terry Aaron
Tisseli, Patrizia
John Garry, Montana
Price, Stefan
Klagosky, Janus
Macleod, column
Man, samuel edward
Panchal, Terry Aaron
Tisseli, Patrizia
John Garry, Montana
Application Number:
JP2016509468A
Publication Date:
September 12, 2018
Filing Date:
April 24, 2014
Export Citation:
Assignee:
Janssen Pharmaceuticals N.B.
International Classes:
C07D471/04; A61K31/506; A61K31/5377; A61P35/00; A61P43/00
Domestic Patent References:
| JP2011525915A | ||||
| JP2011526931A |
Foreign References:
| WO2012123522A1 | ||||
| WO2010042337A1 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Junko Kobayashi
Norio Omori
Yasuhito Suzuki
Junko Kobayashi
Norio Omori
Yasuhito Suzuki
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