Title:
肺癌におけるＲＯＳキナーゼ
Document Type and Number:
Japanese Patent JP6404423
Kind Code:
B2
Abstract:
The invention provides the identification of the presence of polypeptides with R08 kinase activity in mammalian lung cancer. In some embodiments, the polypeptide with R08 kinase activity is the result of a fusion between a ROS-encoding polynucleotide and a polynucleotide encoding a second (non-ROS) polypeptide. Three different fusion partners of R08 are described, namely proteins encoded by the FIG gene, the SLCB4A2 gene, and the CD74 gene. The invention enables new methods for determining the presence of a polypeptide with R08 kinase activity in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer (e.g., an lung cancer).
Inventors:
Victoria McGuinness Rimkunas
Herbert Hark
Tin-Ray Gu
Ilan Guo
Anthony Paul Possemato
Catherine Eleanor Crosby
Megan Ann Tucker
Cynthia Reeves
Herbert Hark
Tin-Ray Gu
Ilan Guo
Anthony Paul Possemato
Catherine Eleanor Crosby
Megan Ann Tucker
Cynthia Reeves
Application Number:
JP2017173626A
Publication Date:
October 10, 2018
Filing Date:
September 11, 2017
Export Citation:
Assignee:
Cell Signaling Technology Incorporated
International Classes:
G01N33/574; A61K31/4545; A61K31/506; A61K45/00; A61P35/00; A61P43/00; C12Q1/68
Domestic Patent References:
| JP2011501669A |
Foreign References:
| WO2010093928A2 | ||||
| WO2009051846A2 |
Other References:
ACQUAVIVA J,THE MULTIFACETED ROLES OF THE RECEPTOR TYROSINE KINASE ROS IN DEVELOPMENT AND CANCER,BBA - REVIEWS ON CANCER,NL,ELSEVIER SCIENCE BV,2009年 1月 1日,V1795 N1,P37-52
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi