Title:
親和性成熟抗ＣＣＲ４ヒト化モノクローナル抗体および使用法
Document Type and Number:
Japanese Patent JP6411329
Kind Code:
B2
Abstract:
The present invention provides affinity matured humanized monoclonal antibodies, bi-specific antibodies, antibody conjugates, and fusion proteins that bind to the chemokine receptor CCR4. This antibody is derived from mAb 1567 and recognizes the same epitope. Binding of the antibodies disclosed herein to CCR4 inhibits ligand-mediated activities and is used to treat symptoms of cancer. Moreover, the antibody is used in combination with vaccines to suppress the activity of regulatory T cells.
More Like This:
| JP7444471 | Glycan-dependent immunotherapy molecules |
| JP2013040160 | USE OF ANTI-CD83 AGONIST ANTIBODY FOR TREATING AUTOIMMUNE DISEASE |
| WO/2011/051349 | ANTIBODIES TO ION CHANNELS |
Inventors:
Marasco Wayne A.
Switch Huahua
Chu Quang
Chandae-Kuan
Switch Huahua
Chu Quang
Chandae-Kuan
Application Number:
JP2015510508A
Publication Date:
October 24, 2018
Filing Date:
May 06, 2013
Export Citation:
Assignee:
Dana Faber Cancer Institute, Incorporated
International Classes:
C07K16/28; A61K39/395; A61P35/00; A61P37/04; A61P43/00; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13
Foreign References:
| WO2009086514A1 | ||||
| WO2010142952A2 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto