Title:
CFC症候群モデルマウスの作製とその治療法の確立
Document Type and Number:
Japanese Patent JP6429306
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a model mouse showing characteristics of CFC syndrome.SOLUTION: There is provided a CFC syndrome model mouse embryo having hetero junction type and wild type BRAF gene and variant BRAF gene.
Inventors:
Shinichi Inoue
Yoko Aoki
Yoichi Matsubara
Yoko Aoki
Yoichi Matsubara
Application Number:
JP2014063166A
Publication Date:
November 28, 2018
Filing Date:
March 26, 2014
Export Citation:
Assignee:
Tohoku University
International Classes:
A01K67/027; A61K31/16; A61K31/166; A61K31/4184; A61K31/55; A61K45/00; A61K45/06; A61P9/00; A61P25/00; A61P43/00; G01N33/15; G01N33/50
Other References:
UROSEVIC, Jelena et al.,Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome,PNAS,2011年 3月22日,vol.108, no. 2,p. 5015-5020,Supporting information p. 1-6
Cancer Res,2005年12月,vol. 65, no. 24,p. 11493-11500
Human Molecular Genetics,2014年,vol. 23, issue. 25,p. 6553-6566
SARKOZY, Anna et al.,Germline BRAF Mutations in Noonan, LEOPARD, and Cardiofaciocutaneous Syndromes: Molecular Diversity and Associated Phenotypic Spectrum,Human Mutation,2009年,vol. 30, no. 4,p. 695-702
Full=Serine/threonine-protein kinase B-raf,2014年 2月19日,Database UniProtKB, [online], Accession No. P28028,
ANASTASAKI, Corina et al.,Continual low-level MEK inhibition ameliorates cardio-facio-cutaneous phenotypes in zebrafish,Disease Models & Mechanisms,2012年,vol.5,p. 546-552
Cancer Res,2005年12月,vol. 65, no. 24,p. 11493-11500
Human Molecular Genetics,2014年,vol. 23, issue. 25,p. 6553-6566
SARKOZY, Anna et al.,Germline BRAF Mutations in Noonan, LEOPARD, and Cardiofaciocutaneous Syndromes: Molecular Diversity and Associated Phenotypic Spectrum,Human Mutation,2009年,vol. 30, no. 4,p. 695-702
Full=Serine/threonine-protein kinase B-raf,2014年 2月19日,Database UniProtKB, [online], Accession No. P28028,
ANASTASAKI, Corina et al.,Continual low-level MEK inhibition ameliorates cardio-facio-cutaneous phenotypes in zebrafish,Disease Models & Mechanisms,2012年,vol.5,p. 546-552
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Nozomi Murabayashi
Satoshi Fujita
Nozomi Murabayashi