Title:
真菌の細胞壁多糖成分を標的とする抗体
Document Type and Number:
Japanese Patent JP6434958
Kind Code:
B2
Abstract:
A compound comprising one or more polysaccharide moieties each independently represented by the formula β(1→4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.
Inventors:
Mision Frances
Cummer frank
Ren Quishu
Cummer frank
Ren Quishu
Application Number:
JP2016500727A
Publication Date:
December 05, 2018
Filing Date:
March 06, 2014
Export Citation:
Assignee:
WELLSTAT VACCINES, LLC
International Classes:
C08B37/08; A61K39/00; A61K39/395; A61P31/10; C07K14/00; C07K16/14
Domestic Patent References:
| JP7002679A | ||||
| JP3163092A |
Other References:
Sorlier, P. et al.,Journal of biomedical materials research - Part A,2003年,vol.67, no.3,p.766-774
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Yasunori Matsuhashi
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Satoshi Morikawa
Hiroyuki Tomita
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Yasunori Matsuhashi
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Satoshi Morikawa
Hiroyuki Tomita
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