Title:
光学活性2級アルコールの製造方法
Document Type and Number:
Japanese Patent JP6437187
Kind Code:
B2
Abstract:
The object of this invention is to provide a method for producing an optically active secondary alcohol at a high optical purity by hydrogenating a substrate carbonyl compound at a high efficiency using as a catalyst a ruthenium complex bearing as a ligand certain optically active diphosphine compound and a readily synthesized amine compound. The method of producing an optically active secondary alcohol according to the present invention is characterized in that a substrate carbonyl compound (provided that 3-quinuclidinone, 3-quinuclidinone derivative having a substituent, and a ketone having an aromatic hydrocarbon group and a heterocycle are excluded) is reacted with hydrogen and/or a hydrogen donating compound in the presence of a ruthenium complex selected from the compounds expressed by following general formula (1) RuXYAB (1) [in the general formula (1), X and Y are the same or different from each other and denote a hydrogen atom or an anionic group, A denotes an optically active diphosphine expressed by the general formula (2), B denotes an amine compound expressed by following general formula (3)].
Inventors:
Takeaki Katayama
Kunihiko Tsutsumi
Kunihiko Murata
Takeshi Okuma
Arai Noriyoshi
Kunihiko Tsutsumi
Kunihiko Murata
Takeshi Okuma
Arai Noriyoshi
Application Number:
JP2013156036A
Publication Date:
December 12, 2018
Filing Date:
July 26, 2013
Export Citation:
Assignee:
Kanto Chemical Co., Ltd.
National University Corporation Hokkaido University
National University Corporation Hokkaido University
International Classes:
C07C33/20; C07C29/145; C07C33/46; C07C41/26; C07C43/23
Domestic Patent References:
| JP2007536338A | ||||
| JP201151929A |
Foreign References:
| WO2006103756A1 |
Other References:
Organometallics,2005年,Vol.24, No.7,p.1660-1669
Attorney, Agent or Firm:
Kiyoji Kuzuwa