Title:
抗原特異的Ｔ細胞反応を誘導するための免疫原エンハンサーとしての融合タンパク質
Document Type and Number:
Japanese Patent JP6449384
Kind Code:
B2
Abstract:
A fusion protein for use as an immunogen enhancer for enhancing antigen-specific T cell responses is disclosed. The fusion protein comprises: (a) an antigen-presenting cell (APC)-binding domain or a CD91 receptor-binding domain; (b) a protein transduction domain; and (c) an antigen of a pathogen, wherein the APC-binding domain or the CD91 receptor-binding domain is located at the N-terminus of the fusion protein, and the antigen of the pathogen is located at the C-terminus of the protein transduction domain. The protein transduction domain is selected from the group consisting of: (i) a fusion polypeptide, comprising a T cell sensitizing signal-transducing peptide, a linker, and a translocation peptide; (ii) a T cell-sensitizing signal-transducing peptide; and (iii) a translocation peptide of 34-112 amino acid residues in length.
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Inventors:
Butterfly
Wu, Chiamao
Woo Jin Min
Chan, Siu Kang
Wu, Chiamao
Woo Jin Min
Chan, Siu Kang
Application Number:
JP2017130836A
Publication Date:
January 09, 2019
Filing Date:
July 04, 2017
Export Citation:
Assignee:
THEVAX GENETICS VACCINE CO., LTD.
International Classes:
C07K19/00; A61K39/00; A61K39/12; A61K39/245; A61K39/265; A61K39/39; A61P31/12; A61P35/00; A61P37/04; C07K14/005; C07K14/09; C07K14/125; C07K14/21; C07K14/47
Foreign References:
| US7335361 | ||||
| US20120213811 | ||||
| WO2004069207A2 | ||||
| WO2004069206A2 |
Attorney, Agent or Firm:
sk patent corporation
Akihiko Okuno
Hiroyuki Ito
Akihiko Okuno
Hiroyuki Ito