Title:
抗体重鎖のＣ末端の修飾による補体依存性細胞傷害の調節
Document Type and Number:
Japanese Patent JP6454547
Kind Code:
B2
Abstract:
Antibody variants having decreased or increased ability to mediate CDC due to modifications at the C-terminus of their heavy chains are described. Methods of generating such antibodies, as well as nucleotide constructs and host cells suitable for the production of said antibodies are also described.
Inventors:
Parlen Paul
Van Berkel Patrick
Van den Bremer Ewald
Van Berkel Patrick
Van den Bremer Ewald
Application Number:
JP2014517838A
Publication Date:
January 16, 2019
Filing Date:
July 06, 2012
Export Citation:
Assignee:
GENMAB A/S
International Classes:
C12N15/63; C12P21/08
Domestic Patent References:
| JP2010536396A | ||||
| JP2009542750A |
Foreign References:
| WO2005090405A1 |
Other References:
Biochemical and Biophysical Research Communications,2000年,vol.276,p.965-969
Journal of Biotechnology,2009年,vol.139,p.318-325
Plant Biotechnology Journal ,2007年,vol.5,p.657-663
PNAS,2003年,vol.100,no.9,p.5022-5027
Journal of Pharmaceutical sciences,2008年,vol.97,no.7,p.2426-2447
nature biotechnology,2006年,vol.24,no.12,p.1591-1597
Journal of Biotechnology,2009年,vol.139,p.318-325
Plant Biotechnology Journal ,2007年,vol.5,p.657-663
PNAS,2003年,vol.100,no.9,p.5022-5027
Journal of Pharmaceutical sciences,2008年,vol.97,no.7,p.2426-2447
nature biotechnology,2006年,vol.24,no.12,p.1591-1597
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto