Title:
抗がん薬物とするアリールアミン置換のキノキサリン
Document Type and Number:
Japanese Patent JP6462868
Kind Code:
B2
Abstract:
The present invention provides new compounds of formula I(a)-I(d) and II, The compounds can inhibit cancerous inhibitor of protein phosphate 2A (CIP2A), can be used as protein phosphate 2A (PP2A) accelerator and oncoprotein SET antagonist, and can treat cancers effectively.
Inventors:
Chen Kunfeng
Takashi Xiao
Chen Shiro
Takashi Xiao
Chen Shiro
Application Number:
JP2017521275A
Publication Date:
January 30, 2019
Filing Date:
July 07, 2015
Export Citation:
Assignee:
Chen Kunfeng
Takashi Xiao
Takashi Xiao
International Classes:
C07D241/44; A61K31/337; A61K31/44; A61K31/498; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07D403/12
Domestic Patent References:
| JP2008515979A |
Foreign References:
| WO2002020463A1 | ||||
| DE288610A |
Other References:
Waisser, K. et al.,Pharmazie,1997年,52(10),797-798
Khan, S. A. et al.,Synthesis and antimicrobial activity of 2,3-di-substituted quinoxalines,Indian Journal of Heterocyclic Chemistry,2008年,18(2),197-198
Babu, P. Vijaya et al.,Ligand/PTC-free intramolecular Heck reaction: synthesis of pyrroloquinoxalines and their evaluation against PDE4/luciferase/oral cancer cell growth in vitro and zebrafish in vivo,Organic & Biomolecular Chemistry ,2013年,11(39),6680-6685
Waisser, K. et al.,Antimycobacterial activity of some 2,3-dianilinoquinoxaline derivatives with substituents in position 6,Scientia Pharmaceutica,1997年,65(3),109-112
CAS Registry,20 December 2004; 2,3-Quinoxalinediamine, N2,N3-bis(phenylmethyl)-CAS Registry No.799787-14-7
CAS Registry,06 September 2001; 2,3-Quinoxalinediamine, N2,N3-bis(4-methoxyphenyl)-6-nitro-CAS Registry No.354989-33-6
CAS Registry,20 October 2000; Phenol, 4,4'-[(6-nitro-2,3-quinoxalinediyl)diimino]bis- (9CI)CAS Registry No.297763-23-6
CAS Registry,15 February 2002; 2,3-Quinoxalinediamine, N2,N3-bis(4-fluorophenyl)-6-nitro-CAS Registry No.392710-13-3
CAS Registry,19 April 2001; Phenol, 4,4'-(2,3-quinoxalinediyldiimino)bis- (9CI)CAS Registry No.331848-77-2
CAS Registry,18 April 2008; 2-Quinoxalinamine, 3-chloro-N-(3-chlorophenyl)-CAS Registry No.1015590-66-5
CAS Registry,24 September 2001; 2-Quinoxalinamine, 3-chloro-N-(3-nitrophenyl)-CAS Registry No.358371-27-4
CAS Registry,29 November 2000; 2,3-Quinoxalinediamine, 6-nitro-N2,N3-bis[3-(trifluoromethyl)phenyl]-CAS Registry No.304883-93-0
CAS Registry,16 September 2002; 3H-Pyrazol-3-one, 4,4'-(2,3-quinoxalinediyldiimino)bis[1,2-dihydro-1,5-dimethyl-2-phenyl- (9CI)CAS Registry No.451524-00-8
Khan, S. A. et al.,Synthesis and antimicrobial activity of 2,3-di-substituted quinoxalines,Indian Journal of Heterocyclic Chemistry,2008年,18(2),197-198
Babu, P. Vijaya et al.,Ligand/PTC-free intramolecular Heck reaction: synthesis of pyrroloquinoxalines and their evaluation against PDE4/luciferase/oral cancer cell growth in vitro and zebrafish in vivo,Organic & Biomolecular Chemistry ,2013年,11(39),6680-6685
Waisser, K. et al.,Antimycobacterial activity of some 2,3-dianilinoquinoxaline derivatives with substituents in position 6,Scientia Pharmaceutica,1997年,65(3),109-112
CAS Registry,20 December 2004; 2,3-Quinoxalinediamine, N2,N3-bis(phenylmethyl)-CAS Registry No.799787-14-7
CAS Registry,06 September 2001; 2,3-Quinoxalinediamine, N2,N3-bis(4-methoxyphenyl)-6-nitro-CAS Registry No.354989-33-6
CAS Registry,20 October 2000; Phenol, 4,4'-[(6-nitro-2,3-quinoxalinediyl)diimino]bis- (9CI)CAS Registry No.297763-23-6
CAS Registry,15 February 2002; 2,3-Quinoxalinediamine, N2,N3-bis(4-fluorophenyl)-6-nitro-CAS Registry No.392710-13-3
CAS Registry,19 April 2001; Phenol, 4,4'-(2,3-quinoxalinediyldiimino)bis- (9CI)CAS Registry No.331848-77-2
CAS Registry,18 April 2008; 2-Quinoxalinamine, 3-chloro-N-(3-chlorophenyl)-CAS Registry No.1015590-66-5
CAS Registry,24 September 2001; 2-Quinoxalinamine, 3-chloro-N-(3-nitrophenyl)-CAS Registry No.358371-27-4
CAS Registry,29 November 2000; 2,3-Quinoxalinediamine, 6-nitro-N2,N3-bis[3-(trifluoromethyl)phenyl]-CAS Registry No.304883-93-0
CAS Registry,16 September 2002; 3H-Pyrazol-3-one, 4,4'-(2,3-quinoxalinediyldiimino)bis[1,2-dihydro-1,5-dimethyl-2-phenyl- (9CI)CAS Registry No.451524-00-8
Attorney, Agent or Firm:
Aiwa Patent Business Corporation