Title:
抗がん剤としての三環式化合物
Document Type and Number:
Japanese Patent JP6466456
Kind Code:
B2
Abstract:
The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
Inventors:
Derek Jay Norris
George Budelka
Ashbinicmar Buoy Gabai
Claude A Quesnel
Patrice Jill
Daniel O'Malley
Wayne Baccaro
Lee Francis Wye
Mikel Buoy De Benedetto
Andrew P. Degunan
Fan Haitian
Matthew Di Hill
Hong Hoang
William Di Schmitz
John E Starlet Jr.
Wen-Ching Han
John S. Tokalski
Sunil Kumar Mandal
George Budelka
Ashbinicmar Buoy Gabai
Claude A Quesnel
Patrice Jill
Daniel O'Malley
Wayne Baccaro
Lee Francis Wye
Mikel Buoy De Benedetto
Andrew P. Degunan
Fan Haitian
Matthew Di Hill
Hong Hoang
William Di Schmitz
John E Starlet Jr.
Wen-Ching Han
John S. Tokalski
Sunil Kumar Mandal
Application Number:
JP2016542692A
Publication Date:
February 06, 2019
Filing Date:
December 23, 2014
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61P35/00; A61P35/02
Domestic Patent References:
| JP2012512886A |
Foreign References:
| WO2014086739A1 | ||||
| WO2013046635A1 | ||||
| WO2012145173A1 | ||||
| WO2005051318A2 | ||||
| WO1993014080A1 |
Other References:
GORLITZER K,REAKTIONEN VON 4,5-DIHYDRO-4-OXO-1H-PYRIDO(3,2-B)INDOL-2-CARBONSAURE-ESTERN 1-3,DIE PHARMAZIE,ドイツ,GOVI VERLAG PHARMAZEUTISCHER VERLAG GMBH,2000年 1月 1日,VOL:55, NR:4,,PAGE(S):273 - 281
HEWINGS, David S. et al.,Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain-Acetyl-lysine Interactions,Journal of Medicinal Chemistry,2012年,55(22),9393-9413,DOI: 10.1021/jm300915b
CONWAY, Stuart J.,Bromodomains: Are Readers Right for Epigenetic Therapy?,ACS Medicinal Chemistry Letters,2012年,3(9),691-694,DOI: 10.1021/ml300221t
HEWINGS, David S. et al.,Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain-Acetyl-lysine Interactions,Journal of Medicinal Chemistry,2012年,55(22),9393-9413,DOI: 10.1021/jm300915b
CONWAY, Stuart J.,Bromodomains: Are Readers Right for Epigenetic Therapy?,ACS Medicinal Chemistry Letters,2012年,3(9),691-694,DOI: 10.1021/ml300221t
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Mizuhara Masahiro
Nagatoshi Shinagawa
Mizuhara Masahiro