Title:
抗菌薬の標的としての鞭毛及びニードル複合体（インジェクトソーム）のループ
Document Type and Number:
Japanese Patent JP6474727
Kind Code:
B2
Abstract:
The present invention relates to a method for screening a compound that inhibits secretion of toxins into host-cell cytoplasm by virulent bacteria using a needle type III secretion system. The compound of the invention is selected by screening for a compound which interacts with a loop region of the cytoplasmic domain of the membrane protein FlhB from Salmonella typhimurium or a paralog thereof. Compositions including the compound of the invention, use of the compound, and methods of treating disorders caused by virulent bacteria are also provided.
Inventors:
Samate Fadel Alexi
Mesheryakov Vladimir A
Hideyuki Matsunami
Akira Kitao
Mesheryakov Vladimir A
Hideyuki Matsunami
Akira Kitao
Application Number:
JP2015542885A
Publication Date:
February 27, 2019
Filing Date:
February 27, 2014
Export Citation:
Assignee:
Okinawa Institute of Science and Technology Graduate School
International Classes:
A61K31/505; C12Q1/02; A61K31/522; A61K45/00; A61P31/04; G01N33/15; G01N33/50
Foreign References:
| WO2010118046A1 |
Other References:
Med. Chem. Commun., 2013, Vol. 4, p. 68-79
Antimicrob. Agents Chemother., 2009, Vol. 53, No. 2, p. 385-392
J. Mol. Biol., 2011, Vol. 409, No. 4, p. 558-573
Molecular Microbiology, 2008, Vol. 68, No. 6, p. 1485-1501
PLoS ONE, 2012.03, Vol. 7, No. 3, e34039
Antimicrob. Agents Chemother., 2009, Vol. 53, No. 2, p. 385-392
J. Mol. Biol., 2011, Vol. 409, No. 4, p. 558-573
Molecular Microbiology, 2008, Vol. 68, No. 6, p. 1485-1501
PLoS ONE, 2012.03, Vol. 7, No. 3, e34039
Attorney, Agent or Firm:
Patent business corporation Tsukuni