Title:
糖類系バイオマーカーおよび治療剤
Document Type and Number:
Japanese Patent JP6476529
Kind Code:
B2
Abstract:
The invention provides antibodies that specifically bind to an epitope containing N-acetylglucosamine and specifically bind to an epitope comprising N-acetyl-galactosamine expressed by a cancer cell or an inflammatory cell. Further provided are methods for treating gastrointestinal diseases characterized by inflammatory cells in the intestines or colon in an individual by administering to the individual an antibody that specifically binds to an epitope containing N-acetylglucosamine and specifically binds to an epitope comprising N-acetyl-galactosamine.
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Inventors:
One, Fool
Application Number:
JP2017511761A
Publication Date:
March 06, 2019
Filing Date:
August 21, 2015
Export Citation:
Assignee:
B&H BIOTECHNOLOGIES, LLC
International Classes:
C12N15/13; A61K39/395; A61P1/04; A61P35/00; C07K16/30; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Domestic Patent References:
| JP90002761A1 | ||||
| JP2005535723A | ||||
| JP2006501441A |
Foreign References:
| WO2002077649A1 |
Other References:
Comer, F. I. et al.,Characterization of amouse monoclonal antibody specific for O-linked N-acetylglucosamine,Anal. Biochem.,2001年,Vol. 293,pp. 169-177
Springer, G. F.,T and Tn, general carcinoma autoantigens,Science,1984年,Vol. 224,pp. 1198-1206
Springer, G. F. et al.,Blood group MN precursors as human breast carcinoma-associated antigens and naturally occuring human cytotoxins against them,Cancer,1976年,Vol. 37,pp. 169-176
Smorodin, E. P. et al.,The characterization of IgG antibodiesto GalNAc beta-terminated glycans of gastric cancer survivors,Exp. Oncol.,2014年 3月,Vol. 36,pp. 38-43
Ito, H. et al.,Monoclonal IgM in two patients with motor neuron disease bind to the carbohydrate antigens Gal(beta 1-3)GalNAc and Gal(beta 1-3)GlcNAc,J. Neuroimmunol. ,1988年,Vol. 19,pp. 245-253
Seow, C. H. et al.,Novel anti-glycan antibodies related to inflammatory bowel disease diagnosis and phenotype,Am. J. Gastroenterol.,2009年,Vol. 104,pp. 1426-1434
Nakatani, Y. et al.,IgG anti-GalNAc-GD1a antibody inhibits the voltage-dependent calcium channel currents in PC12 pheochromocytoma cells,Exp. Neurol.,2007年,Vol. 204,pp. 380-386
西 達也,白血球はどのようにして炎症部位に集まるのか,化学と生物,1995年,Vol. 33,pp. 83-90
佐々木 克敏,接着分子セレクチンの糖鎖リガンドの生合成に関与するα2,3-シアル酸転移酵素とα1,3フコース転移酵素の発現クローニングと応用,東京大学学位論文データベース[online],2006年,[retrieved on 4/26/2018],URL,http://gakui.dl.itc.u-tokyo.ac.jp/cgi-bin/gazo.cgi?no=216644
小林 基弘,慢性炎症性疾患における硫酸化糖類の機能,信州医誌,2009年,Vol. 57,pp. i-ii
Springer, G. F.,T and Tn, general carcinoma autoantigens,Science,1984年,Vol. 224,pp. 1198-1206
Springer, G. F. et al.,Blood group MN precursors as human breast carcinoma-associated antigens and naturally occuring human cytotoxins against them,Cancer,1976年,Vol. 37,pp. 169-176
Smorodin, E. P. et al.,The characterization of IgG antibodiesto GalNAc beta-terminated glycans of gastric cancer survivors,Exp. Oncol.,2014年 3月,Vol. 36,pp. 38-43
Ito, H. et al.,Monoclonal IgM in two patients with motor neuron disease bind to the carbohydrate antigens Gal(beta 1-3)GalNAc and Gal(beta 1-3)GlcNAc,J. Neuroimmunol. ,1988年,Vol. 19,pp. 245-253
Seow, C. H. et al.,Novel anti-glycan antibodies related to inflammatory bowel disease diagnosis and phenotype,Am. J. Gastroenterol.,2009年,Vol. 104,pp. 1426-1434
Nakatani, Y. et al.,IgG anti-GalNAc-GD1a antibody inhibits the voltage-dependent calcium channel currents in PC12 pheochromocytoma cells,Exp. Neurol.,2007年,Vol. 204,pp. 380-386
西 達也,白血球はどのようにして炎症部位に集まるのか,化学と生物,1995年,Vol. 33,pp. 83-90
佐々木 克敏,接着分子セレクチンの糖鎖リガンドの生合成に関与するα2,3-シアル酸転移酵素とα1,3フコース転移酵素の発現クローニングと応用,東京大学学位論文データベース[online],2006年,[retrieved on 4/26/2018],URL,http://gakui.dl.itc.u-tokyo.ac.jp/cgi-bin/gazo.cgi?no=216644
小林 基弘,慢性炎症性疾患における硫酸化糖類の機能,信州医誌,2009年,Vol. 57,pp. i-ii
Attorney, Agent or Firm:
Kyuichi Ueki
Hisahiko Ueki
Tadashi Sugakawa
Hiroaki Ito
Akemi Takeoka
Hisahiko Ueki
Tadashi Sugakawa
Hiroaki Ito
Akemi Takeoka